{"id":"3360a7d2-b0fa-5682-b3ea-51a74bbbe77c","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-heart-autophagy","predicate":"increases","statement":"Oral spermidine enhanced cardiac autophagy, mitophagy and mitochondrial respiration in the mouse aging study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a88d4a64-a894-5544-b9ce-7fae654e4f31","mechanism_event_label":"Several measured cardiac maintenance processes changed.","subject":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"object":{"id":"bb0245dd-c18c-510c-9f88-4a74ce6323e8","slug":"mouse-cardiac-autophagy-mitophagy","display_name":"Mouse cardiac autophagy and mitophagy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a88d4a64-a894-5544-b9ce-7fae654e4f31","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-heart-autophagy-event","event_type":"observed_relationship","label":"Several measured cardiac maintenance processes changed.","description":"Oral spermidine enhanced cardiac autophagy, mitophagy and mitochondrial respiration in the mouse aging study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"bb0245dd-c18c-510c-9f88-4a74ce6323e8","slug":"mouse-cardiac-autophagy-mitophagy","display_name":"Mouse cardiac autophagy and mitophagy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Aging mice receiving spermidine in drinking water.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a clinical cardiac-treatment trial; separate downstream mechanisms remain model dependent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Several measured cardiac maintenance processes changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cardioprotection and lifespan extension by the natural polyamine spermidine. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27841876/ · DOI 10.1038/nm.4222","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c6e9d0cc-7b72-57f6-9e3f-79772d9a0412","evidence_kind":"source_excerpt","locator":"Lines 326-332","start_line":326,"end_line":332,"excerpt":"## spermidine-heart-autophagy\nSeveral measured cardiac maintenance processes changed.\nOral spermidine enhanced cardiac autophagy, mitophagy and mitochondrial respiration in the mouse aging study.\nModel: Aging mice receiving spermidine in drinking water.\nLimitations: Not a clinical cardiac-treatment trial; separate downstream mechanisms remain model dependent.\nEvidence access: Primary abstract\nCardioprotection and lifespan extension by the natural polyamine spermidine. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27841876/ · DOI 10.1038/nm.4222","model_system":"Aging mice receiving spermidine in drinking water.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4348f3f8-0180-58a3-b61c-55d03bb322d2","stable_key":"import-88eb7407-f147-558b-889b-0c89c4e0aa4a","title":"Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8eec8784bc2bd0384cfd53c6603c4ced8e53c227d9ab29ed85594c43e34c68ef","revision_id":"7c421a18-4526-59f6-b84e-4be533bc35ac","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}