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It is cooling of anaesthetised rodents, not cold water immersion of a person.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Cold water immersion research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"cold-water-immersion","display_name":"Cold water immersion","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Raising the cold protein protected the brain and extended life; removing it cancelled the benefit of cooling itself.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cold-p25607368] RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration. 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It is cooling of anaesthetised rodents, not cold water immersion of a person.\nexposure: Artificial cooling with rewarming; RBM3 overexpression or knockdown\nevidence_span: {\"source_cache\": \"artifacts/cold-research/25607368.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d5cf22cc43a38b28c13d58f29dc4ada326eb6617d86ea4a704638c675406cf48\", \"start_char\": 0, \"end_char\": 2081, \"text_sha256\": \"d5cf22cc43a38b28c13d58f29dc4ada326eb6617d86ea4a704638c675406cf48\"}\n[cold-p25607368] RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration. (2015). https://pubmed.ncbi.nlm.nih.gov/25607368/ DOI: 10.1038/nature14142","model_system":"Cooled laboratory rodents and mouse models of prion disease and Alzheimer-type neurodegeneration","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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