{"id":"3309285e-0d88-59b0-bad3-601a2340b72c","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-dehydration","predicate":"increases_retention","statement":"Dehydration can promote lithium retention and toxicity.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a389652e-e325-57a2-9f52-143bf93bcfab","mechanism_event_label":"Fluid loss can amplify exposure.","subject":{"id":"afc22967-249a-5b3f-9ace-d7da2414f114","slug":"human-volume-depletion","display_name":"Human volume depletion/dehydration","entity_type_key":"cellular_process"},"object":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a389652e-e325-57a2-9f52-143bf93bcfab","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-dehydration-event","event_type":"observed_relationship","label":"Fluid loss can amplify exposure.","description":"Dehydration can promote lithium retention and toxicity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"afc22967-249a-5b3f-9ace-d7da2414f114","slug":"human-volume-depletion","display_name":"Human volume depletion/dehydration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"57835bde-69fc-5cc2-b68e-1254c4db4da6","slug":"human-serum-lithium","display_name":"Human serum lithium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"d31225b7-8e94-5857-9ea1-67ac794b1f15","slug":"water","display_name":"H2O","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Official prescribing information","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Official prescribing information, sections 5, 7 and 12; updated 2026-07-06, prescribing text revised 2023-06.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Regulatory clinical statement; not an experiment resolving a single molecular target. No dosing recommendation follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Fluid loss can amplify exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium and lithium carbonate prescribing information; DailyMed set c84cce95-cfcb-4426-aac6-d2f48f946ada, updated July 6 2026; prescribing text revised June 2023 · 2026 · https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c84cce95-cfcb-4426-aac6-d2f48f946ada","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d4218ca2-b923-58a6-92c7-d960da03cf58","evidence_kind":"source_excerpt","locator":"Lines 568-574","start_line":568,"end_line":574,"excerpt":"## lithium-dehydration\nFluid loss can amplify exposure.\nDehydration can promote lithium retention and toxicity.\nModel: Official prescribing information, sections 5, 7 and 12; updated 2026-07-06, prescribing text revised 2023-06.\nLimitations: Regulatory clinical statement; not an experiment resolving a single molecular target. No dosing recommendation follows.\nEvidence access: Official prescribing information\nLithium and lithium carbonate prescribing information; DailyMed set c84cce95-cfcb-4426-aac6-d2f48f946ada, updated July 6 2026; prescribing text revised June 2023 · 2026 · https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c84cce95-cfcb-4426-aac6-d2f48f946ada","model_system":"Official prescribing information, sections 5, 7 and 12; updated 2026-07-06, prescribing text revised 2023-06.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"dc67e965ba78458cf2d88d000d687641d9104354115ab16529a3a64941bd777d","revision_id":"4af127bf-9ccc-516b-9481-fafd453c2c35","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}