{"id":"32a0a828-f526-5d88-bffa-b2311718ff31","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-mypt","predicate":"reduces","statement":"EGCG dephosphorylated MYPT1 Thr696 through 67LR and eEF1A.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"fac59e87-6a56-50da-9d47-4f4ff50e25df","mechanism_event_label":"EGCG removed an inhibitory phosphorylation mark in this pathway.","subject":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"object":{"id":"3330b57b-ee90-5293-963b-2022227283ae","slug":"mypt1-thr696-phosphorylation","display_name":"MYPT1 Thr696 phosphorylation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fac59e87-6a56-50da-9d47-4f4ff50e25df","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-mypt-event","event_type":"observed_relationship","label":"EGCG removed an inhibitory phosphorylation mark in this pathway.","description":"EGCG dephosphorylated MYPT1 Thr696 through 67LR and eEF1A.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"22e1b8eb-f35f-5afa-be20-b0534df9f6be","slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3330b57b-ee90-5293-963b-2022227283ae","slug":"mypt1-thr696-phosphorylation","display_name":"MYPT1 Thr696 phosphorylation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"85e65054-3bd4-53b5-a5f0-2286061f8bf0","slug":"laminin-receptor-67kda","display_name":"67-kDa laminin receptor state / 67LR","entity_type_key":"protein_state"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fd0edc10-cd26-5e13-af04-a8ab865108a4","slug":"eef1a-family","display_name":"Eukaryotic elongation factor 1A family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"f3e7f45d-c517-54f4-bdf9-6628399b127b","slug":"mypt1-family","display_name":"Myosin phosphatase targeting subunit 1 family / MYPT1","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Genetic screen, cell signaling and experimental tumor-growth models.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pathway dependency in these models does not establish human cancer treatment or a dietary threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"EGCG removed an inhibitory phosphorylation mark in this pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18079119/ · DOI 10.1074/jbc.m707892200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"11a6923f-c8e8-5aac-9e96-136051362103","evidence_kind":"source_excerpt","locator":"Lines 36-42","start_line":36,"end_line":42,"excerpt":"## egcg-mypt\nEGCG removed an inhibitory phosphorylation mark in this pathway.\nEGCG dephosphorylated MYPT1 Thr696 through 67LR and eEF1A.\nModel: Genetic screen, cell signaling and experimental tumor-growth models.\nLimitations: Pathway dependency in these models does not establish human cancer treatment or a dietary threshold.\nEvidence access: primary abstract.\nGreen tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18079119/ · DOI 10.1074/jbc.m707892200","model_system":"Genetic screen, cell signaling and experimental tumor-growth models.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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