{"id":"31dffaaa-db47-5510-b8f6-4fba248a4693","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-monacolin-variability","predicate":"has_measured_variability_in","statement":"Monacolin K was undetected in two of 28 brands; the other 26 ranged from 0.09 to 5.48 mg per 1,200 mg red yeast rice.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"985b4d50-624f-5481-a019-5b206bb37955","mechanism_event_label":"Equal masses of product delivered very different measured amounts.","subject":{"id":"c099293f-a298-5019-b797-70850e18fce7","slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"},"object":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"evidence_count":1,"mechanism_event":{"id":"985b4d50-624f-5481-a019-5b206bb37955","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-monacolin-variability-event","event_type":"observed_relationship","label":"Equal masses of product delivered very different measured amounts.","description":"Monacolin K was undetected in two of 28 brands; the other 26 ranged from 0.09 to 5.48 mg per 1,200 mg red yeast rice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c099293f-a298-5019-b797-70850e18fce7","slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5d0ea9bb-cce8-5e13-aa3d-37db2215386e","slug":"lovastatin","display_name":"Lovastatin / monacolin K lactone","entity_type_key":"drug"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"UHPLC-based analysis of products purchased for the 2017 study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A historical sample, not a measurement of current products or batches.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Equal masses of product delivered very different measured amounts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[28641460] Variability in strength of red yeast rice supplements purchased from mainstream retailers. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28641460/ · DOI 10.1177/2047487317715714","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8fb63411-ceff-5a72-a159-91a48294eae9","evidence_kind":"source_excerpt","locator":"Lines 20-26","start_line":20,"end_line":26,"excerpt":"## red-yeast-rice-monacolin-variability\nEqual masses of product delivered very different measured amounts.\nMonacolin K was undetected in two of 28 brands; the other 26 ranged from 0.09 to 5.48 mg per 1,200 mg red yeast rice.\nModel: UHPLC-based analysis of products purchased for the 2017 study.\nLimitations: A historical sample, not a measurement of current products or batches.\nEvidence access: Primary abstract\n[28641460] Variability in strength of red yeast rice supplements purchased from mainstream retailers. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28641460/ · DOI 10.1177/2047487317715714","model_system":"UHPLC-based analysis of products purchased for the 2017 study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}