{"id":"31cf54bc-c24b-5dfa-8ae2-c0cea73ebeaa","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-calhm1-release","predicate":"when_deleted_reduces","statement":"Calhm1 knockout reduced taste-evoked ATP release without eliminating taste-cell excitability to the stimuli.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7c491ed8-d558-5156-bc1c-c50ab09f9069","mechanism_event_label":"A cell can detect a stimulus yet fail to transmit its message.","subject":{"id":"e6024a40-c127-5833-9faf-9aab86a5b37f","slug":"mouse-calhm1","display_name":"Mouse CALHM1 / Calhm1","entity_type_key":"protein"},"object":{"id":"c6900a47-3ab8-58ec-93c1-7dd4fcb80683","slug":"mouse-type-ii-taste-atp-release","display_name":"Mouse type II taste-cell ATP release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7c491ed8-d558-5156-bc1c-c50ab09f9069","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-calhm1-release-event","event_type":"observed_relationship","label":"A cell can detect a stimulus yet fail to transmit its message.","description":"Calhm1 knockout reduced taste-evoked ATP release without eliminating taste-cell excitability to the stimuli.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e6024a40-c127-5833-9faf-9aab86a5b37f","slug":"mouse-calhm1","display_name":"Mouse CALHM1 / Calhm1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c6900a47-3ab8-58ec-93c1-7dd4fcb80683","slug":"mouse-type-ii-taste-atp-release","display_name":"Mouse type II taste-cell ATP release","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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