{"id":"31605f4d-c089-5c7f-b3db-d6bbde7cbea8","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-urine-nitrate","predicate":"increased","statement":"The highest regimen increased urinary nitrate from 92 to 125 micromol/mmol creatinine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b5c44843-915e-5e68-b3f5-9593cec30d8d","mechanism_event_label":"Another NO-related marker changed.","subject":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"object":{"id":"eb1b8f31-d177-50c9-b537-922997870c53","slug":"urinary-nitrate-excretion","display_name":"Urinary nitrate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b5c44843-915e-5e68-b3f5-9593cec30d8d","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-urine-nitrate-event","event_type":"biochemical_relationship","label":"Another NO-related marker changed.","description":"The highest regimen increased urinary nitrate from 92 to 125 micromol/mmol creatinine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"downstream_substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6c8e2535-0002-5b29-bb3d-36cb341b85d2","slug":"asymmetric-dimethylarginine","display_name":"Asymmetric dimethylarginine / ADMA","entity_type_key":"small_molecule"},"role":"measured_inhibitor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6d2f509b-3a5b-5a38-b3e7-b148581edec9","slug":"cgmp","display_name":"Cyclic guanosine monophosphate","entity_type_key":"small_molecule"},"role":"downstream_marker","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"eb1b8f31-d177-50c9-b537-922997870c53","slug":"urinary-nitrate-excretion","display_name":"Urinary nitrate excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/citrulline-research/17662090.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b\", \"start_char\": 0, \"end_char\": 1980, \"text_sha256\": \"32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind placebo-controlled crossover study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Citrulline 0.75, 1.5 or 3 g twice daily versus arginine formulations; one-week periods","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small short trial; NO-related urine markers do not establish a clinically meaningful vascular benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Citrulline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 20 healthy volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Another NO-related marker changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[citrulline-p17662090] Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. (2008). https://pubmed.ncbi.nlm.nih.gov/17662090/ DOI: 10.1111/j.1365-2125.2007.02990.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma amino acids, urine NO markers and brachial FMD","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"88c6daf0-c47a-5c79-9564-7376e02acfbf","evidence_kind":"source_excerpt","locator":"Lines 905-916","start_line":905,"end_line":916,"excerpt":"### citrulline-urine-nitrate\nThe highest regimen increased urinary nitrate from 92 to 125 micromol/mmol creatinine.\nCondition category: normal\nnutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Another NO-related marker changed.\norganism: Human, 20 healthy volunteers\ntissue_or_cell_type: Plasma amino acids, urine NO markers and brachial FMD\nexperimental_model: Double-blind placebo-controlled crossover study\nlimitations: Small short trial; NO-related urine markers do not establish a clinically meaningful vascular benefit.\nexposure: Citrulline 0.75, 1.5 or 3 g twice daily versus arginine formulations; one-week periods\nevidence_span: {\"source_cache\": \"artifacts/citrulline-research/17662090.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b\", \"start_char\": 0, \"end_char\": 1980, \"text_sha256\": \"32e6ddf6d263120576f0f73c7fe3dd104904f3c0ba0a1c3f69cdca5751c4fa3b\"}\n[citrulline-p17662090] Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. (2008). https://pubmed.ncbi.nlm.nih.gov/17662090/ DOI: 10.1111/j.1365-2125.2007.02990.x","model_system":"Double-blind placebo-controlled crossover study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [citrulline-p17662090] Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. (2008). https://pubmed.ncbi.nlm.nih.gov/17662090/ DOI: 10.1111/j.1365-2125.2007.02990.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"112fd375-aa2a-59d2-8afd-6b2849bb79ee","stable_key":"import-a9828b14-fbd7-57bf-9e01-0d52d1b42a1f","title":"Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"3720442dbabc28cacefd2145c7c97bfb937df26dca8527fde219ecd3735ed558","revision_id":"41ac8493-b004-59d7-99b3-8a3ca7163d3a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}