{"id":"3103f88a-47ed-5082-b6a6-97e5129db7bc","stable_key":"920dfea8-62e3-5bd4-8b18-d19f86eb8295:egt-mito-uptake","predicate":"is_taken_up_into","statement":"Mass spectrometry detected ergothioneine entry into isolated mitochondria and mitochondrial presence after treating cells and animals.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a7ce0e7f-109d-5fc5-aed8-961227a47a14","mechanism_event_label":"Cell entry and mitochondrial entry are separate transport questions.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"9d1942d9-042b-5c51-b852-de2e4d9ea358","slug":"mammalian-mitochondrial-ergothioneine-uptake","display_name":"Ergothioneine uptake into isolated mammalian mitochondria","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a7ce0e7f-109d-5fc5-aed8-961227a47a14","stable_key":"920dfea8-62e3-5bd4-8b18-d19f86eb8295:egt-mito-uptake-event","event_type":"biochemical_relationship","label":"Cell entry and mitochondrial entry are separate transport questions.","description":"Mass spectrometry detected ergothioneine entry into isolated mitochondria and mitochondrial presence after treating cells and animals.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9d1942d9-042b-5c51-b852-de2e4d9ea358","slug":"mammalian-mitochondrial-ergothioneine-uptake","display_name":"Ergothioneine uptake into isolated mammalian mitochondria","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract; numerical exposures and tissue-specific methods not available in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated mitochondria, treated cells and animals; tissue and dose details not extracted from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived research curation; not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mitochondrial localisation alone does not establish disease prevention or identify the membrane transporter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine mitochondrial supplement; shared molecular requirements are not demonstrated dietary interactions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cell entry and mitochondrial entry are separate transport questions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Fong et al. 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