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(2010). https://pubmed.ncbi.nlm.nih.gov/19965379/ DOI: 10.1126/science.1179907","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Purified copper chaperones","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"34a541c8-e9e2-5d78-beec-97f22f79ded9","evidence_kind":"source_excerpt","locator":"Lines 1600-1611","start_line":1600,"end_line":1611,"excerpt":"### mo-ttm-copper-cluster\nTetrathiomolybdate formed a stable sulfur-bridged copper-molybdenum cluster with yeast Atx1.\nCondition category: normal\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A sulfur-rich molybdenum drug can trap copper in a protein complex.\norganism: Saccharomyces cerevisiae proteins; comparison with animal drug complexes\ntissue_or_cell_type: Purified copper chaperones\nexperimental_model: Yeast Atx1 crystallography, spectroscopy and copper-transfer experiments\nlimitations: Drug and yeast-protein chemistry; not evidence that normal human dietary molybdate strips copper from proteins.\nexposure: Tetrathiomolybdate exposure\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/19965379.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"166eb55335870bc9843fdb0c61becaa318603b25c601bbfa8f69a469dab89e57\", \"start_char\": 0, \"end_char\": 950, \"text_sha256\": \"166eb55335870bc9843fdb0c61becaa318603b25c601bbfa8f69a469dab89e57\"}\n[mo-p19965379] Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation. 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