{"id":"30f8858e-8600-5fac-a2ab-882adfc97176","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-psip1","predicate":"supports_arginine_response","statement":"Knockout reduced the arginine-associated survival benefit.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a02ba991-20eb-56ed-bd0c-4109dd158036","mechanism_event_label":"This regulator contributed to the survival response.","subject":{"id":"15727e1b-a597-5bcc-a9fe-e8b112470f53","slug":"psip1","display_name":"Human PSIP1 transcriptional coactivator","entity_type_key":"protein"},"object":{"id":"8743181c-048d-53e1-8fdc-cd8cf009d796","slug":"t-cell-survival-after-il2-withdrawal","display_name":"Activated T-cell survival after IL-2 withdrawal","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a02ba991-20eb-56ed-bd0c-4109dd158036","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-tcell-psip1-event","event_type":"observed_relationship","label":"This regulator contributed to the survival response.","description":"Knockout reduced the arginine-associated survival benefit.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15727e1b-a597-5bcc-a9fe-e8b112470f53","slug":"psip1","display_name":"Human PSIP1 transcriptional coactivator","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8743181c-048d-53e1-8fdc-cd8cf009d796","slug":"t-cell-survival-after-il2-withdrawal","display_name":"Activated T-cell survival after IL-2 withdrawal","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human T-cell clones; CRISPR perturbation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish a sole sensor or benefit against human cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"This regulator contributed to the survival response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"2efd9f18-9b6a-58cd-bf13-8d0547989bea","evidence_kind":"source_excerpt","locator":"Lines 254-260","start_line":254,"end_line":260,"excerpt":"## arg-tcell-psip1\nThis regulator contributed to the survival response.\nKnockout reduced the arginine-associated survival benefit.\nModel: Human T-cell clones; CRISPR perturbation.\nLimitations: Does not establish a sole sensor or benefit against human cancer.\nEvidence access: Full-text results, Figures 2 and 6, Europe PMC PMC5075284; primary abstract.\nL-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27745970/ · DOI 10.1016/j.cell.2016.09.031","model_system":"Human T-cell clones; CRISPR perturbation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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