{"id":"30cc618c-5b05-5def-902d-d129dda002e1","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-atm-response","predicate":"activates","statement":"DIM rapidly activated ATM and enhanced ATM-linked DNA-damage-response signaling in the studied cell system.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"95f00d56-f1ae-59ed-a53f-ed4235fb4748","mechanism_event_label":"The compound also affected a DNA-damage sensor.","subject":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"object":{"id":"243ad948-2281-53f8-8e53-32247253668d","slug":"atm","display_name":"Human ATM kinase","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"95f00d56-f1ae-59ed-a53f-ed4235fb4748","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-atm-response-event","event_type":"biochemical_relationship","label":"The compound also affected a DNA-damage sensor.","description":"DIM rapidly activated ATM and enhanced ATM-linked DNA-damage-response signaling in the studied cell system.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"875a94da-1eee-50d2-b5c1-e4316c2a8f45","slug":"nf-kappab-signaling","display_name":"NF-kappa-B signaling","entity_type_key":"cellular_process"},"role":"associated_survival_signal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"243ad948-2281-53f8-8e53-32247253668d","slug":"atm","display_name":"Human ATM kinase","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/24127581.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc\", \"start_char\": 0, \"end_char\": 1379, \"text_sha256\": \"6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell signaling and rodent radiation experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Submicromolar cell exposures and multidose rodent DIM schedules","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No human radioprotection trial. Lack of protection in tested tumor xenografts cannot establish safety with all radiotherapy or cancer types.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cultured cells and irradiated rodents; breast-tumor xenografts separately","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The compound also affected a DNA-damage sensor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p24127581] DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. (2013). https://pubmed.ncbi.nlm.nih.gov/24127581/ DOI: 10.1073/pnas.1308206110","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"ATM-mediated damage response","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8cdd77ed-9093-5c69-99eb-571a00c869e5","evidence_kind":"source_excerpt","locator":"Lines 1429-1440","start_line":1429,"end_line":1440,"excerpt":"### dim-atm-response\nDIM rapidly activated ATM and enhanced ATM-linked DNA-damage-response signaling in the studied cell system.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The compound also affected a DNA-damage sensor.\norganism: Cultured cells and irradiated rodents; breast-tumor xenografts separately\ntissue_or_cell_type: ATM-mediated damage response\nexperimental_model: Cell signaling and rodent radiation experiments\nlimitations: No human radioprotection trial. Lack of protection in tested tumor xenografts cannot establish safety with all radiotherapy or cancer types.\nexposure: Submicromolar cell exposures and multidose rodent DIM schedules\nevidence_span: {\"source_cache\": \"artifacts/dim-research/24127581.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc\", \"start_char\": 0, \"end_char\": 1379, \"text_sha256\": \"6e938b73271132ed6dc4ed9f3a4d7bb6cf85fd3071df159c17c9fcef93b901fc\"}\n[dim-p24127581] DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. (2013). https://pubmed.ncbi.nlm.nih.gov/24127581/ DOI: 10.1073/pnas.1308206110","model_system":"Cell signaling and rodent radiation experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [dim-p24127581] DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. (2013). https://pubmed.ncbi.nlm.nih.gov/24127581/ DOI: 10.1073/pnas.1308206110","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b6d70682-97f9-5893-a03c-f9f88836033c","stable_key":"import-182336c6-ed36-5ec6-8a09-25c31096262e","title":"Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"31e14060de904976d2f5d439f2bc9c8a99a72d34626c562c78429025e050d404","revision_id":"611094c1-a9cf-5b9b-b255-ac70b571696a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}