{"id":"3076997a-42fe-51b5-8cdf-44073750eb29","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-vital-cancer","predicate":"has-estimated-effect-on","statement":"D3 versus placebo estimate: HR0.96; 95% CI0.88–1.06; P=0.47.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d109c430-8d06-51a6-8502-68fb7d7c048b","mechanism_event_label":"The supplement did not significantly lower invasive cancer incidence.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"23714a51-23c4-5f04-a1f6-040d1edefdd6","slug":"invasive-cancer-incidence","display_name":"Incidence of invasive cancer","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d109c430-8d06-51a6-8502-68fb7d7c048b","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-vital-cancer-event","event_type":"observed_intervention","label":"The supplement did not significantly lower invasive cancer incidence.","description":"D3 versus placebo estimate: HR0.96; 95% CI0.88–1.06; P=0.47.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"23714a51-23c4-5f04-a1f6-040d1edefdd6","slug":"invasive-cancer-incidence","display_name":"Incidence of invasive cancer","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"VITAL primary prevention RCT; 25, 871 adults; median 5.3 years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"D3 2000 IU/day versus placebo; randomized factorial omega 3 allocation; median 5.3 years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary prevention population; secondary mortality finding is not the primary cancer-incidence endpoint. This record does not summarize later pooled analyses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The supplement did not significantly lower invasive cancer incidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[manson2019] Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. (2019). https://pubmed.ncbi.nlm.nih.gov/30415629/ DOI: 10.1056/nejmoa1809944","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical events","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f4fe56a3-325e-521b-b05e-a5468b4e4454","evidence_kind":"source_excerpt","locator":"Lines 1535-1546","start_line":1535,"end_line":1546,"excerpt":"### vd-vital-cancer\nD3 versus placebo estimate: HR0.96; 95% CI0.88–1.06; P=0.47.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The supplement did not significantly lower invasive cancer incidence.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical events\nexperimental_model: VITAL primary prevention RCT; 25, 871 adults; median 5.3 years\nlimitations: Primary prevention population; secondary mortality finding is not the primary cancer-incidence endpoint. This record does not summarize later pooled analyses.\nexposure: D3 2000 IU/day versus placebo; randomized factorial omega 3 allocation; median 5.3 years.\ncross_nutrient: false\n[manson2019] Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. (2019). https://pubmed.ncbi.nlm.nih.gov/30415629/ DOI: 10.1056/nejmoa1809944","model_system":"VITAL primary prevention RCT; 25, 871 adults; median 5.3 years","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [manson2019] Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. (2019). https://pubmed.ncbi.nlm.nih.gov/30415629/ DOI: 10.1056/nejmoa1809944","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}