{"id":"306f8bd7-62a6-54c2-8c35-2309c0b4315b","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-insulin-potassium","predicate":"reduces","statement":"Urinary potassium excretion fell from 66 to 21 microequivalents/min while plasma potassium also decreased.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"7ffa5be8-0032-5837-bd52-11f9f2c2e812","mechanism_event_label":"Blood potassium and urinary loss changed together.","subject":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"object":{"id":"9c8754c9-e29e-5538-abce-b3521ba4bb32","slug":"renal-potassium-excretion","display_name":"Renal potassium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7ffa5be8-0032-5837-bd52-11f9f2c2e812","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-insulin-potassium-event","event_type":"observed_relationship","label":"Blood potassium and urinary loss changed together.","description":"Urinary potassium excretion fell from 66 to 21 microequivalents/min while plasma potassium also decreased.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9c8754c9-e29e-5538-abce-b3521ba4bb32","slug":"renal-potassium-excretion","display_name":"Renal potassium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Insulin-clamp mechanism, not a fasting or refeeding-syndrome trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Blood potassium and urinary loss changed together.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1120786/ · DOI 10.1172/JCI107996","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"13a27ff0-6e59-5c95-af70-66bd76bb0c6f","evidence_kind":"source_excerpt","locator":"Lines 456-462","start_line":456,"end_line":462,"excerpt":"## fast-insulin-potassium\nBlood potassium and urinary loss changed together.\nUrinary potassium excretion fell from 66 to 21 microequivalents/min while plasma potassium also decreased.\nModel: Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.\nLimitations: Insulin-clamp mechanism, not a fasting or refeeding-syndrome trial.\nEvidence access: Primary abstract\nThe effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1120786/ · DOI 10.1172/JCI107996","model_system":"Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}