{"id":"306e4fba-89e4-51b1-a929-a900da9db8d8","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-k-depletion-activates-reabsorption","predicate":"depletion-increases","statement":"K-depleted rats preferentially retained K over Rb, especially when distal buffer delivery increased and residual secretion was inhibited.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"5fa128df-4260-5d78-968e-b565e032e178","mechanism_event_label":"The depleted kidney can increase potassium recovery; rubidium does not track it perfectly.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"4f4d3deb-c00d-5990-bb3e-74032d531a12","slug":"renal-potassium-reabsorption","display_name":"Renal potassium reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5fa128df-4260-5d78-968e-b565e032e178","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:renal-k-depletion-activates-reabsorption-event","event_type":"biochemical_relationship","label":"The depleted kidney can increase potassium recovery; rubidium does not track it perfectly.","description":"K-depleted rats preferentially retained K over Rb, especially when distal buffer delivery increased and residual secretion was inhibited.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"causal-subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4f4d3deb-c00d-5990-bb3e-74032d531a12","slug":"renal-potassium-reabsorption","display_name":"Renal potassium reabsorption","entity_type_key":"cellular_process"},"role":"measured-target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"retained-ion","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8155f62e-a68f-5256-851d-30c33b497aaf","slug":"rubidium-ion","display_name":"Rubidium ion","entity_type_key":"ion"},"role":"comparator-ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"78506253-1833-5641-89d3-c07bcfcc73a9","slug":"amiloride","display_name":"Amiloride","entity_type_key":"small_molecule"},"role":"secretion-inhibitor","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"Primary abstract; K/Rb comparisons with buffer and secretion manipulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Clearance studies with amiloride and buffer-delivery manipulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Clearance evidence does not identify the H,K-ATPase isoform or directly localize all transport.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The depleted kidney can increase potassium recovery; rubidium does not track it perfectly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[1992-k-reabsorption] Effect of K depletion on renal K and Rb excretion: evidence for activation of K reabsorption (1992). https://pubmed.ncbi.nlm.nih.gov/1405312/ DOI: 10.1038/ki.1992.286","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney; distal absorptive pathway inferred","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a379dd37-e9a9-5a66-9151-88dd026cba0f","evidence_kind":"source_excerpt","locator":"Lines 523-533","start_line":523,"end_line":533,"excerpt":"### renal-k-depletion-activates-reabsorption\nK-depleted rats preferentially retained K over Rb, especially when distal buffer delivery increased and residual secretion was inhibited.\nCondition category: nutrient_deficiency\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The depleted kidney can increase potassium recovery; rubidium does not track it perfectly.\norganism: Rattus norvegicus\ntissue_or_cell_type: Kidney; distal absorptive pathway inferred\nexperimental_model: Clearance studies with amiloride and buffer-delivery manipulation\nlimitations: Clearance evidence does not identify the H,K-ATPase isoform or directly localize all transport.\nevidence_location: Primary abstract; K/Rb comparisons with buffer and secretion manipulation.\n[1992-k-reabsorption] Effect of K depletion on renal K and Rb excretion: evidence for activation of K reabsorption (1992). https://pubmed.ncbi.nlm.nih.gov/1405312/ DOI: 10.1038/ki.1992.286","model_system":"Clearance studies with amiloride and buffer-delivery manipulation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [1992-k-reabsorption] Effect of K depletion on renal K and Rb excretion: evidence for activation of K reabsorption (1992). https://pubmed.ncbi.nlm.nih.gov/1405312/ DOI: 10.1038/ki.1992.286","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}