{"id":"304c2feb-e237-537c-9666-4715a0f1d472","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-gdh-ammonia-limit","predicate":"does_not_resolve_tested","statement":"Hyperammonemia persisted despite protein/leucine restriction in the reported twelve-patient series.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"b122d6ed-7b65-5f69-a2f6-e700c2bd40da","mechanism_event_label":"Changing a regulator or diet did not correct every downstream outcome.","subject":{"id":"2b0e728b-8a9b-5872-8ce2-aa26ff960a59","slug":"human-glud1-protein-leucine-restriction","display_name":"Protein/leucine restriction in the GLUD1 patient series","entity_type_key":"cellular_process"},"object":{"id":"c8ea485f-fda8-5410-a6f4-26f8c54c0153","slug":"human-glud1-persistent-hyperammonemia","display_name":"Persistent hyperammonemia in human GLUD1 disease","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b122d6ed-7b65-5f69-a2f6-e700c2bd40da","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-gdh-ammonia-limit-event","event_type":"observed_relationship","label":"Changing a regulator or diet did not correct every downstream outcome.","description":"Hyperammonemia persisted despite protein/leucine restriction in the reported twelve-patient series.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b0e728b-8a9b-5872-8ce2-aa26ff960a59","slug":"human-glud1-protein-leucine-restriction","display_name":"Protein/leucine restriction in the GLUD1 patient series","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c8ea485f-fda8-5410-a6f4-26f8c54c0153","slug":"human-glud1-persistent-hyperammonemia","display_name":"Persistent hyperammonemia in human GLUD1 disease","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7a2271b6-fae8-5b08-b6ae-df7a0f96919b","slug":"glud1","display_name":"GLUD1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"cef15a0b-c3bf-5dba-8e69-a20c118cd411","slug":"human-glud1-hyperinsulinism-hyperammonemia","display_name":"Human GLUD1 hyperinsulinism/hyperammonemia","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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