{"id":"30379842-223a-5b9c-99f7-99ed4c7126bb","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-hf-biomarker-response","predicate":"increases_without_clinical_improvement","statement":"Erythrocyte thiamine pyrophosphate and urinary thiamine increased in the 2019 chronic-HF trial despite no functional benefit.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8785d554-41a1-55fd-a80f-3423c853f980","mechanism_event_label":"A higher vitamin measurement did not guarantee better heart function.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8785d554-41a1-55fd-a80f-3423c853f980","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-hf-biomarker-response-event","event_type":"observed_intervention","label":"A higher vitamin measurement did not guarantee better heart function.","description":"Erythrocyte thiamine pyrophosphate and urinary thiamine increased in the 2019 chronic-HF trial despite no functional benefit.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b64e359c-3dc6-5146-ab61-768deb93680e","slug":"urinary-thiamine-excretion","display_name":"Urinary thiamine excretion","entity_type_key":"cellular_process"},"role":"parallel_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"187db168-8028-5ce6-9f8b-4bc61ebad1a0","slug":"thiamine-diphosphate","display_name":"Thiamine diphosphate","entity_type_key":"small_molecule"},"role":"measured_metabolite","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fff22d5c-def5-56a2-9dde-f9667bece0a5","slug":"erythrocyte-thdp-concentration","display_name":"Erythrocyte thiamine diphosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [b1-keith2019] Thiamin supplementation does not improve left ventricular ejection fraction in ambulatory heart failure patients: a randomized controlled trial (2019). https://pubmed.ncbi.nlm.nih.gov/31504093/ DOI: 10.1093/ajcn/nqz192","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}