{"id":"3026dcef-ef4b-5613-8693-f397750ae9da","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-ugt1a9-3g","predicate":"forms","statement":"Human UGT1A9 formed Luteolin 3′-O-glucuronide in the luteolin-conjugation study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b7e4157a-790e-58bc-8723-16bee3208b17","mechanism_event_label":"The conjugation position defines a distinct product.","subject":{"id":"0721c8f5-4c36-500f-9df4-f34e5eeaadba","slug":"ugt1a9","display_name":"Human UDP-glucuronosyltransferase 1A9 / UGT1A9","entity_type_key":"protein"},"object":{"id":"3249c76e-5379-5540-9d6b-9ad0de95d29b","slug":"luteolin-3-prime-o-glucuronide","display_name":"Luteolin 3′-O-glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b7e4157a-790e-58bc-8723-16bee3208b17","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-ugt1a9-3g-event","event_type":"observed_relationship","label":"The conjugation position defines a distinct product.","description":"Human UGT1A9 formed Luteolin 3′-O-glucuronide in the luteolin-conjugation study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0721c8f5-4c36-500f-9df4-f34e5eeaadba","slug":"ugt1a9","display_name":"Human UDP-glucuronosyltransferase 1A9 / UGT1A9","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3249c76e-5379-5540-9d6b-9ad0de95d29b","slug":"luteolin-3-prime-o-glucuronide","display_name":"Luteolin 3′-O-glucuronide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fea4f3f0-7c05-59a2-9332-445b9d4f8fb0","slug":"udp-glucuronic-acid","display_name":"UDP-glucuronic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant enzymes and UGT1A9-expressing HeLa cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Engineered expression; not a human organ concentration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The conjugation position defines a distinct product.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Breast cancer resistance protein-mediated efflux of luteolin glucuronides in HeLa cells overexpressing UDP-glucuronosyltransferase 1A9. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24092055/ · DOI 10.1007/s11095-013-1207-0","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f56d8b32-0e1c-55c0-96b2-435e3f812d35","evidence_kind":"source_excerpt","locator":"Lines 52-58","start_line":52,"end_line":58,"excerpt":"## luteolin-ugt1a9-3g\nThe conjugation position defines a distinct product.\nHuman UGT1A9 formed Luteolin 3′-O-glucuronide in the luteolin-conjugation study.\nModel: Recombinant enzymes and UGT1A9-expressing HeLa cells.\nLimitations: Engineered expression; not a human organ concentration.\nEvidence access: Primary abstract\nBreast cancer resistance protein-mediated efflux of luteolin glucuronides in HeLa cells overexpressing UDP-glucuronosyltransferase 1A9. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24092055/ · DOI 10.1007/s11095-013-1207-0","model_system":"Recombinant enzymes and UGT1A9-expressing HeLa cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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