{"id":"2fef7b7a-ab4a-5b90-817c-298f9135e8a1","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-sfxn1-respiration","predicate":"supports","statement":"SFXN1 deficiency impaired complex III biogenesis, assembly and activity and compromised coenzyme Q levels.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d0d43a1f-d739-5311-a598-6261ae9fd5d7","mechanism_event_label":"A transport defect can affect the respiratory chain as well as one-carbon metabolism.","subject":{"id":"8d8fb144-4bb5-5b97-8a22-207c2e9c5206","slug":"sfxn1","display_name":"Human sideroflexin 1 / SFXN1","entity_type_key":"protein"},"object":{"id":"d5ea6be7-3afc-5a80-8d9e-941899ac61d8","slug":"human-sfxn1-complex-iii","display_name":"Human mitochondrial complex III integrity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d0d43a1f-d739-5311-a598-6261ae9fd5d7","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-sfxn1-respiration-event","event_type":"observed_relationship","label":"A transport defect can affect the respiratory chain as well as one-carbon metabolism.","description":"SFXN1 deficiency impaired complex III biogenesis, assembly and activity and compromised coenzyme Q levels.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8d8fb144-4bb5-5b97-8a22-207c2e9c5206","slug":"sfxn1","display_name":"Human sideroflexin 1 / SFXN1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d5ea6be7-3afc-5a80-8d9e-941899ac61d8","slug":"human-sfxn1-complex-iii","display_name":"Human mitochondrial complex III integrity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cultured-cell mitochondrial carrier characterization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is a transporter-loss experiment, not evidence that serine supplements raise CoQ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A transport defect can affect the respiratory chain as well as one-carbon metabolism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33730581/ · DOI 10.1016/j.celrep.2021.108869","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"584b465b-62cc-5e7e-acf2-5bb82fd6cfbd","evidence_kind":"source_excerpt","locator":"Lines 158-164","start_line":158,"end_line":164,"excerpt":"## l-serine-sfxn1-respiration\nA transport defect can affect the respiratory chain as well as one-carbon metabolism.\nSFXN1 deficiency impaired complex III biogenesis, assembly and activity and compromised coenzyme Q levels.\nModel: Human cultured-cell mitochondrial carrier characterization.\nLimitations: This is a transporter-loss experiment, not evidence that serine supplements raise CoQ.\nEvidence access: Primary abstract\nThe mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33730581/ · DOI 10.1016/j.celrep.2021.108869","model_system":"Human cultured-cell mitochondrial carrier characterization.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"70bcf57a-36bb-563f-9073-2d616e5f155a","stable_key":"import-649e861b-265a-5912-bc36-3a73e53ef892","title":"L-Serine: synthesis, one-carbon metabolism, lipids and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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