{"id":"2fbdda56-4f82-5ceb-a45e-0e3503e43d9c","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:fkbp-fk506-inhibits-calcineurin","predicate":"inhibits","statement":"The FKBP-FK506 complex also competitively binds and inhibits calcineurin, making calcineurin the common target of two structurally unrelated immunophilin-drug complexes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8c9ca705-7393-5d35-a7d6-7ca8865fabf6","mechanism_event_label":"The FKBP-FK506 complex also competitively binds and inhibits calcineurin, making calcineurin the common target of two structurally unrelated immunophilin-drug complexes.","subject":{"id":"2ba4a540-b7b8-5f7d-b359-274b207ae9d2","slug":"fkbp-fk506","display_name":"FKBP-FK506 complex","entity_type_key":"protein_complex"},"object":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"8c9ca705-7393-5d35-a7d6-7ca8865fabf6","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:fkbp-fk506-inhibits-calcineurin-event","event_type":"biochemical_relationship","label":"The FKBP-FK506 complex also competitively binds and inhibits calcineurin, making calcineurin the common target of two structurally unrelated immunophilin-drug complexes.","description":"Calcineurin phosphatase activity","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2ba4a540-b7b8-5f7d-b359-274b207ae9d2","slug":"fkbp-fk506","display_name":"FKBP-FK506 complex","entity_type_key":"protein_complex"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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