{"id":"2f8e7b98-962e-51d6-aed5-5b0ef42f9cd9","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-no-diversion","predicate":"coadministration_reduces","statement":"CLA coadministration reduced labeled NO–deoxyhemoglobin formation and attenuated nitrite-associated vasodilation and platelet inhibition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"263fef14-abb8-58ba-9209-337c0bf7cb01","mechanism_event_label":"Making more nitrated lipid coincided with less of another NO response.","subject":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"object":{"id":"5e647a0f-92c6-5a1c-b5ac-c5474e609067","slug":"human-nitrosyl-hemoglobin-formation","display_name":"Human nitrosyl-hemoglobin formation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"263fef14-abb8-58ba-9209-337c0bf7cb01","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-no-diversion-event","event_type":"observed_relationship","label":"Making more nitrated lipid coincided with less of another NO response.","description":"CLA coadministration reduced labeled NO–deoxyhemoglobin formation and attenuated nitrite-associated vasodilation and platelet inhibition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5e647a0f-92c6-5a1c-b5ac-c5474e609067","slug":"human-nitrosyl-hemoglobin-formation","display_name":"Human nitrosyl-hemoglobin formation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"03ffed32-aa18-5d63-96a4-8a7ebedaf7a9","slug":"nitrite","display_name":"Nitrite / NO2(-)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f2a6b7ab-ad41-5ada-8895-41d6ce42f4e4","slug":"nitric-oxide","display_name":"NO","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7468400a-fe41-54c8-b1f9-91ee231c880c","slug":"human-cla-nitrite-vascular-response","display_name":"Human acute blood-pressure response to oral nitrite with CLA","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Acute labeled-nitrite human study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not quantify interactions with prescription nitrates or prove long-term harm.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; 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