{"id":"2f7f6c01-d599-5444-b94c-2ad3a6b73269","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-ahcy-loss","predicate":"limits_accumulation_when_functional","statement":"The index AHCY-deficient patient had very low enzyme activity and markedly elevated plasma SAH, SAM and methionine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"46c0532c-1601-5936-bfe8-0a2d731941dd","mechanism_event_label":"Abundant methyl-donor substrate can coexist with blocked recycling.","subject":{"id":"1a5e2abf-e98c-5ee2-8197-4434fcc1e88a","slug":"ahcy","display_name":"Human adenosylhomocysteinase / AHCY","entity_type_key":"protein"},"object":{"id":"b3cd8fb4-8771-53f8-8c13-1280649f8740","slug":"human-ahcy-sam-sah-accumulation","display_name":"SAM/SAH accumulation in human AHCY deficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"46c0532c-1601-5936-bfe8-0a2d731941dd","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-ahcy-loss-event","event_type":"observed_relationship","label":"Abundant methyl-donor substrate can coexist with blocked recycling.","description":"The index AHCY-deficient patient had very low enzyme activity and markedly elevated plasma SAH, SAM and methionine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1a5e2abf-e98c-5ee2-8197-4434fcc1e88a","slug":"ahcy","display_name":"Human adenosylhomocysteinase / AHCY","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b3cd8fb4-8771-53f8-8c13-1280649f8740","slug":"human-ahcy-sam-sah-accumulation","display_name":"SAM/SAH accumulation in human AHCY deficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e84829b1-0607-558e-8add-aaa3af4747e7","slug":"s-adenosylhomocysteine","display_name":"S-Adenosyl-L-homocysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"5b635b42-bc0d-5c54-aa94-9cf76cd0ed47","slug":"homocysteine","display_name":"Homocysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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