{"id":"2f7278cb-eeb8-5cb4-8f58-c649aba737b1","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-opg","predicate":"increases","statement":"In long-term adult human primary osteoblast cultures, strontium ranelate increased the OPG/RANKL ratio and an OPG secretory response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"de3c0f83-4c48-5f92-9137-5b8dd2c4b779","mechanism_event_label":"Bone-forming cells can change the signals reaching bone-resorbing cells.","subject":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"object":{"id":"02f7fab4-c764-5448-bf91-7b5f6e5f76e5","slug":"tnfrsf11b","display_name":"Osteoprotegerin / TNFRSF11B / OPG","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"de3c0f83-4c48-5f92-9137-5b8dd2c4b779","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-opg-event","event_type":"observed_relationship","label":"Bone-forming cells can change the signals reaching bone-resorbing cells.","description":"In long-term adult human primary osteoblast cultures, strontium ranelate increased the OPG/RANKL ratio and an OPG secretory response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"02f7fab4-c764-5448-bf91-7b5f6e5f76e5","slug":"tnfrsf11b","display_name":"Osteoprotegerin / TNFRSF11B / OPG","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"de7ad036-388f-596d-8766-72afe51b4a67","slug":"tnfsf11","display_name":"RANK ligand / TNFSF11","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human culture, OPG ELISA and gene-expression assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ratio change is not itself a direct measurement of osteoclast resorption.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Bone-forming cells can change the signals reaching bone-resorbing cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18763010/ · DOI 10.1007/s00198-008-0728-6","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a8261f42-6d7d-5cf4-97d4-688ac7750550","evidence_kind":"source_excerpt","locator":"Lines 198-204","start_line":198,"end_line":204,"excerpt":"## strontium-human-opg\nBone-forming cells can change the signals reaching bone-resorbing cells.\nIn long-term adult human primary osteoblast cultures, strontium ranelate increased the OPG/RANKL ratio and an OPG secretory response.\nModel: Human culture, OPG ELISA and gene-expression assays.\nLimitations: Ratio change is not itself a direct measurement of osteoclast resorption.\nEvidence access: Primary abstract\nStrontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response. · 2009 · https://pubmed.ncbi.nlm.nih.gov/18763010/ · DOI 10.1007/s00198-008-0728-6","model_system":"Human culture, OPG ELISA and gene-expression assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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