{"id":"2f5c1af0-097f-5178-80e6-e47053e82cf4","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-plcb2-loss","predicate":"when_deleted_impairs","statement":"Plcb2 knockout abolished tested sweet, amino-acid and bitter responses while sparing sour and salty responses in the reported mouse experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"49e6967c-3d60-525a-ab9c-350f0fc8bfc0","mechanism_event_label":"Recognizing the molecule requires downstream signaling machinery.","subject":{"id":"45974bbf-1d69-5c63-a3c8-67f704a614c6","slug":"mouse-plcb2","display_name":"Mouse phospholipase C beta 2 / Plcb2","entity_type_key":"protein"},"object":{"id":"0ae3ccb3-32a3-5fe5-b199-e8499888b774","slug":"mouse-gpcr-taste-perception","display_name":"Mouse sweet, bitter and umami taste responses","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"49e6967c-3d60-525a-ab9c-350f0fc8bfc0","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-plcb2-loss-event","event_type":"observed_relationship","label":"Recognizing the molecule requires downstream signaling machinery.","description":"Plcb2 knockout abolished tested sweet, amino-acid and bitter responses while sparing sour and salty responses in the reported mouse experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"45974bbf-1d69-5c63-a3c8-67f704a614c6","slug":"mouse-plcb2","display_name":"Mouse phospholipase C beta 2 / Plcb2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0ae3ccb3-32a3-5fe5-b199-e8499888b774","slug":"mouse-gpcr-taste-perception","display_name":"Mouse sweet, bitter and umami taste responses","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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