{"id":"2ef9702d-786c-5f0b-8b32-96d5cc88c88a","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-human-heart-adducts","predicate":"reduces","statement":"Adding carnosine reduced catecholaldehyde-protein adduct formation in isolated human cardiac mitochondria exposed to norepinephrine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"19cfa34e-0579-5bdb-aa6a-d87ce7084495","mechanism_event_label":"The peptide intercepted damage in an isolated mitochondrial preparation.","subject":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"object":{"id":"ff02cdad-adc7-510e-9540-80608fe3fcbf","slug":"human-cardiac-catecholaldehyde-protein-adducts","display_name":"Human cardiac mitochondrial catecholaldehyde-protein adducts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"19cfa34e-0579-5bdb-aa6a-d87ce7084495","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-human-heart-adducts-event","event_type":"observed_relationship","label":"The peptide intercepted damage in an isolated mitochondrial preparation.","description":"Adding carnosine reduced catecholaldehyde-protein adduct formation in isolated human cardiac mitochondria exposed to norepinephrine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ff02cdad-adc7-510e-9540-80608fe3fcbf","slug":"human-cardiac-catecholaldehyde-protein-adducts","display_name":"Human cardiac mitochondrial catecholaldehyde-protein adducts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e043082-6a19-5f81-be82-d9d0d8dba41d","slug":"dopegal","display_name":"3,4-Dihydroxyphenylglycolaldehyde / DOPEGAL","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cardiac mitochondria ex vivo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence of benefit in patients or a substitute for aldehyde-metabolizing enzymes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The peptide intercepted damage in an isolated mitochondrial preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30191330/ · DOI 10.1007/s00726-018-2647-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d7069117-2bea-52e1-ba5d-e5c14b209236","evidence_kind":"source_excerpt","locator":"Lines 300-306","start_line":300,"end_line":306,"excerpt":"## carnosine-human-heart-adducts\nThe peptide intercepted damage in an isolated mitochondrial preparation.\nAdding carnosine reduced catecholaldehyde-protein adduct formation in isolated human cardiac mitochondria exposed to norepinephrine.\nModel: Human cardiac mitochondria ex vivo.\nLimitations: Not evidence of benefit in patients or a substitute for aldehyde-metabolizing enzymes.\nEvidence access: Primary abstract\nBiochemical characterization of the catecholaldehyde reactivity of L-carnosine and its therapeutic potential in human myocardium. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30191330/ · DOI 10.1007/s00726-018-2647-y","model_system":"Human cardiac mitochondria ex vivo.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}