{"id":"2eee5af1-e940-55e4-aca2-3b3027a2422e","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-bypass-lowcu","predicate":"associated_with","statement":"Copper deficiency was identified in 13 of 136 clinic patients after Roux-en-Y gastric bypass; many had anemia, leukopenia or neuromuscular abnormalities.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ba518b76-3d44-55c7-8ecd-135dbe45ae2f","mechanism_event_label":"After this surgery, some patients developed a clinically important copper shortage.","subject":{"id":"6662b87f-cc61-5483-9798-9d5d647f0a80","slug":"roux-en-y-gastric-bypass","display_name":"Roux-en-Y gastric bypass","entity_type_key":"cellular_process"},"object":{"id":"b1c3755d-8dd5-5fc3-9fb1-cd322f36e09d","slug":"low-copper-status","display_name":"Biochemically low copper status","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ba518b76-3d44-55c7-8ecd-135dbe45ae2f","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-bypass-lowcu-event","event_type":"observed_intervention","label":"After this surgery, some patients developed a clinically important copper shortage.","description":"Copper deficiency was identified in 13 of 136 clinic patients after Roux-en-Y gastric bypass; many had anemia, leukopenia or neuromuscular abnormalities.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6662b87f-cc61-5483-9798-9d5d647f0a80","slug":"roux-en-y-gastric-bypass","display_name":"Roux-en-Y gastric bypass","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b1c3755d-8dd5-5fc3-9fb1-cd322f36e09d","slug":"low-copper-status","display_name":"Biochemically low copper status","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/21876546.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\", \"start_char\": 0, \"end_char\": 1842, \"text_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Post-Roux-en-Y clinic cohort and longitudinal subset","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"136-person clinic cohort; separate longitudinal group of sixteen","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The study observed postoperative deficiency; it did not directly quantify copper absorption in these participants. The 9.6% prevalence is specific to this clinic cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"After this surgery, some patients developed a clinically important copper shortage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and clinical findings after gastric bypass","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"9e86d6ee-cb34-5969-b844-a5a095811caa","evidence_kind":"source_excerpt","locator":"Lines 1391-1402","start_line":1391,"end_line":1402,"excerpt":"### copper-bypass-lowcu\nCopper deficiency was identified in 13 of 136 clinic patients after Roux-en-Y gastric bypass; many had anemia, leukopenia or neuromuscular abnormalities.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: After this surgery, some patients developed a clinically important copper shortage.\norganism: Human\ntissue_or_cell_type: Blood and clinical findings after gastric bypass\nexperimental_model: Post-Roux-en-Y clinic cohort and longitudinal subset\nlimitations: The study observed postoperative deficiency; it did not directly quantify copper absorption in these participants. The 9.6% prevalence is specific to this clinic cohort.\nexposure: 136-person clinic cohort; separate longitudinal group of sixteen\nevidence_span: {\"source_cache\": \"artifacts/copper-research/21876546.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\", \"start_char\": 0, \"end_char\": 1842, \"text_sha256\": \"29b1cc8c0170160c3a7b3449d807bbf309f6e1fa230e453fbfa467fe23fa71c8\"}\n[copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159","model_system":"Post-Roux-en-Y clinic cohort and longitudinal subset","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p21876546] Incidence and prevalence of copper deficiency following roux-en-y gastric bypass surgery. (2012). https://pubmed.ncbi.nlm.nih.gov/21876546/ DOI: 10.1038/ijo.2011.159","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}