{"id":"2edb06a9-1b7a-59ad-b884-f2a55bff2c71","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-mouse-cd38-activation-null","predicate":"no_detected_change_in_recorded_comparison","statement":"CD38-knockout BMDMs retained inflammasome-associated IL-1β responses to the tested activation signals.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"7084ac60-6d15-525d-83bc-e18544f99d30","mechanism_event_label":"CD38-knockout BMDMs retained inflammasome-associated IL-1β responses to the tested activation signals.","subject":{"id":"77c40786-fc17-5efb-887f-52a76163a9ba","slug":"mouse-cd38","display_name":"Mouse CD38","entity_type_key":"protein"},"object":{"id":"c17455e2-5805-55e7-9ecc-09c953115c84","slug":"mouse-il1b","display_name":"Mouse IL-1 beta","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"7084ac60-6d15-525d-83bc-e18544f99d30","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-mouse-cd38-activation-null-event","event_type":"experimental_observation","label":"CD38-knockout BMDMs retained inflammasome-associated IL-1β responses to the tested activation signals.","description":"### api-mouse-cd38-activation-null\n\nCD38-knockout BMDMs retained inflammasome-associated IL-1β responses to the tested activation signals.\nNo required CD38 contribution was demonstrated in these comparisons; not a universal statement about all cell types or inflammatory pathways.\nModel and exposure: LPS-primed mouse macrophages; ATP, MSU and nigericin; n=3.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38. | 2024 | https://pubmed.ncbi.nlm.nih.gov/39840045/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11746122/ | https://doi.org/10.3389/fimmu.2024.1497984 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"77c40786-fc17-5efb-887f-52a76163a9ba","slug":"mouse-cd38","display_name":"Mouse CD38","entity_type_key":"protein"},"role":"tested factor","stoichiometry":null,"state_label":"Cd38 knockout","sequence_order":0,"notes":""},{"entity":{"id":"c17455e2-5805-55e7-9ecc-09c953115c84","slug":"mouse-il1b","display_name":"Mouse IL-1 beta","entity_type_key":"protein"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Cd38 knockout\", \"comparator\": \"Matched wild-type cells\", \"endpoint\": \"CD38-knockout BMDMs retained inflammasome-associated IL-1β responses to the tested activation signals.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"LPS-primed mouse macrophages; ATP, MSU and nigericin; n=3.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"CD38-knockout BMDMs retained inflammasome-associated IL-1β responses to the tested activation signals.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38. | https://pubmed.ncbi.nlm.nih.gov/39840045/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11746122/ | https://doi.org/10.3389/fimmu.2024.1497984","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-mouse-cd38-activation-null; No required CD38 contribution was demonstrated in these comparisons; not a universal statement about all cell types or inflammatory pathways.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d13b293d-96c4-5335-98ac-5ad9f04f647a","evidence_kind":"source_excerpt","locator":"Lines 380-386","start_line":380,"end_line":386,"excerpt":"### api-mouse-cd38-activation-null\n\nCD38-knockout BMDMs retained inflammasome-associated IL-1β responses to the tested activation signals.\nNo required CD38 contribution was demonstrated in these comparisons; not a universal statement about all cell types or inflammatory pathways.\nModel and exposure: LPS-primed mouse macrophages; ATP, MSU and nigericin; n=3.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Apigenin inhibits NLRP3 inflammasome activation in monocytes and macrophages independently of CD38. | 2024 | https://pubmed.ncbi.nlm.nih.gov/39840045/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC11746122/ | https://doi.org/10.3389/fimmu.2024.1497984 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","model_system":"LPS-primed mouse macrophages; ATP, MSU and nigericin; n=3.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}