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abundance differs","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9daea19e-27aa-58c0-b5f8-0b46d0cc0e9e","evidence_kind":"source_excerpt","locator":"Lines 207-216","start_line":207,"end_line":216,"excerpt":"### bbox1-carnitine-formation\nBBOX1 hydroxylates gamma-butyrobetaine to L-carnitine using oxygen, 2-oxoglutarate and ferrous iron.\nPlain language: BBOX1 completes carnitine synthesis.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Kidney, liver and brain; abundance differs\nexperimental_model: Human cDNA expression and human tissue activity assays\nlimitations: Do not generalize full carnitine-synthesis capacity to every tissue.\n[vaz1998] Carnitine biosynthesis: identification of the cDNA encoding human gamma-butyrobetaine hydroxylase (1998). https://pubmed.ncbi.nlm.nih.gov/9753662/ DOI: 10.1006/bbrc.1998.9343\n[rebouche1980] Tissue distribution of carnitine biosynthetic enzymes in man (1980). https://pubmed.ncbi.nlm.nih.gov/6770910/ DOI: 10.1016/0304-4165(80)90133-6","model_system":"Human cDNA expression and human tissue activity assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [vaz1998] Carnitine biosynthesis: identification of the cDNA encoding human gamma-butyrobetaine hydroxylase (1998). https://pubmed.ncbi.nlm.nih.gov/9753662/ DOI: 10.1006/bbrc.1998.9343; [rebouche1980] Tissue distribution of carnitine biosynthetic enzymes in man (1980). https://pubmed.ncbi.nlm.nih.gov/6770910/ DOI: 10.1016/0304-4165(80)90133-6","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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