{"id":"2e89c9e5-b2dc-5826-85e4-5f41ce02e5a3","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-deficiency-rhodopsin","predicate":"supports","statement":"In three vitamin A-deficient patients, slow rod dark adaptation accompanied abnormally slow rhodopsin regeneration.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"02257956-52a0-55d5-b73c-4cacf7762424","mechanism_event_label":"Pigment recovery slowed when vitamin A was depleted.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"23abae59-7a78-58e9-b796-ac3d10db111d","slug":"rhodopsin-regeneration","display_name":"Rhodopsin regeneration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"02257956-52a0-55d5-b73c-4cacf7762424","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-deficiency-rhodopsin-event","event_type":"observed_intervention","label":"Pigment recovery slowed when vitamin A was depleted.","description":"In three vitamin A-deficient patients, slow rod dark adaptation accompanied abnormally slow rhodopsin regeneration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"23abae59-7a78-58e9-b796-ac3d10db111d","slug":"rhodopsin-regeneration","display_name":"Rhodopsin regeneration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Adaptometry and fundus reflectometry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Disease-associated deficiency; no general threshold or intake estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Pigment recovery slowed when vitamin A was depleted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[kemp-1988] Visual function and rhodopsin levels in humans with vitamin A deficiency (1988). https://pubmed.ncbi.nlm.nih.gov/3350064/ DOI: 10.1016/S0014-4835(88)80076-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mid-peripheral retina","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"82d64e5b-9436-5101-99d5-2fd2e819314e","evidence_kind":"source_excerpt","locator":"Lines 997-1006","start_line":997,"end_line":1006,"excerpt":"### a-vision-deficiency-rhodopsin\nIn three vitamin A-deficient patients, slow rod dark adaptation accompanied abnormally slow rhodopsin regeneration.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Pigment recovery slowed when vitamin A was depleted.\norganism: Homo sapiens\ntissue_or_cell_type: Mid-peripheral retina\nexperimental_model: Adaptometry and fundus reflectometry\nlimitations: Disease-associated deficiency; no general threshold or intake estimate.\n[kemp-1988] Visual function and rhodopsin levels in humans with vitamin A deficiency (1988). https://pubmed.ncbi.nlm.nih.gov/3350064/ DOI: 10.1016/S0014-4835(88)80076-9","model_system":"Adaptometry and fundus reflectometry","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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