{"id":"2e449376-365a-52e0-ac2c-2f852dfbb6c5","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-mci-positive","predicate":"attenuates_decline_in","statement":"A 61-person trial reported cognitive/functional stability with lithium versus decline with placebo over two years.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f81ee281-85d2-571f-84d3-b35df7ea12a7","mechanism_event_label":"One small human trial reported a favorable result.","subject":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"object":{"id":"cd0c3be5-4e16-5b9c-930e-0894ec585dc7","slug":"human-mci-lithium-cognition","display_name":"Human MCI cognitive/functional outcomes during lithium trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f81ee281-85d2-571f-84d3-b35df7ea12a7","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-mci-positive-event","event_type":"observed_relationship","label":"One small human trial reported a favorable result.","description":"A 61-person trial reported cognitive/functional stability with lithium versus decline with placebo over two years.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cd0c3be5-4e16-5b9c-930e-0894ec585dc7","slug":"human-mci-lithium-cognition","display_name":"Human MCI cognitive/functional outcomes during lithium trials","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Amnestic MCI; lithium carbonate target 0.25–0.5 mEq/L; NCT01055392.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single trial; population, exposure, endpoints and follow-up differ from later studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"One small human trial reported a favorable result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30947755/ · DOI 10.1192/bjp.2019.76","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ee1b52e5-fdcd-558a-a647-2d2351a7bc57","evidence_kind":"source_excerpt","locator":"Lines 528-534","start_line":528,"end_line":534,"excerpt":"## lithium-mci-positive\nOne small human trial reported a favorable result.\nA 61-person trial reported cognitive/functional stability with lithium versus decline with placebo over two years.\nModel: Amnestic MCI; lithium carbonate target 0.25–0.5 mEq/L; NCT01055392.\nLimitations: Single trial; population, exposure, endpoints and follow-up differ from later studies.\nEvidence access: Primary abstract\nClinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30947755/ · DOI 10.1192/bjp.2019.76","model_system":"Amnestic MCI; lithium carbonate target 0.25–0.5 mEq/L; NCT01055392.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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