{"id":"2e393533-f886-5f51-8bbb-f78a3e2ab519","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-microbial-imp-generation","predicate":"is_precursor_of","statement":"Fecal microbiota from donors with type 2 diabetes generated more imidazole propionate from histidine in the gut simulator than microbiota from donors without diabetes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b3543261-e801-5e35-a5ea-b475ef9a0338","mechanism_event_label":"The same substrate produced different output with different microbial communities.","subject":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"object":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b3543261-e801-5e35-a5ea-b475ef9a0338","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-microbial-imp-generation-event","event_type":"observed_relationship","label":"The same substrate produced different output with different microbial communities.","description":"Fecal microbiota from donors with type 2 diabetes generated more imidazole propionate from histidine in the gut simulator than microbiota from donors without diabetes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human-donor fecal communities in a gut simulator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ex-vivo community behavior is not a controlled human histidine-feeding outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The same substrate produced different output with different microbial communities.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ba6f13c6-6d60-5329-9b96-9f5ba7712128","evidence_kind":"source_excerpt","locator":"Lines 282-288","start_line":282,"end_line":288,"excerpt":"## histidine-microbial-imp-generation\nThe same substrate produced different output with different microbial communities.\nFecal microbiota from donors with type 2 diabetes generated more imidazole propionate from histidine in the gut simulator than microbiota from donors without diabetes.\nModel: Human-donor fecal communities in a gut simulator.\nLimitations: Ex-vivo community behavior is not a controlled human histidine-feeding outcome.\nEvidence access: Primary abstract\nMicrobially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30401435/ · DOI 10.1016/j.cell.2018.09.055","model_system":"Human-donor fecal communities in a gut simulator.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"cb672530ec8b4a4542d0f3957e80ca76bb0449e9f988845b0f7681f623c4ec9b","revision_id":"19a7f26c-d9a1-5411-a81d-025f3d98a452","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}