{"id":"2e28b71a-06a8-5b85-9a39-860ad19a330a","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rbc-glutathione","predicate":"delays","statement":"Added indicaxanthin delayed glutathione depletion during oxidative challenge of beta-thalassemic red cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"052ad1f1-88db-5a49-bf5c-3f8f9483252a","mechanism_event_label":"Added indicaxanthin delayed glutathione depletion during oxidative challenge of beta-thalassemic red cells.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"8d840d3f-7760-5cda-ac1c-eaa7d1162b82","slug":"human-thalassemia-rbc-glutathione-depletion","display_name":"Reduced glutathione depletion in human beta-thalassemic erythrocytes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"052ad1f1-88db-5a49-bf5c-3f8f9483252a","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rbc-glutathione-event","event_type":"observed_relationship","label":"Added indicaxanthin delayed glutathione depletion during oxidative challenge of beta-thalassemic red cells.","description":"Added indicaxanthin delayed glutathione depletion during oxidative challenge of beta-thalassemic red cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8d840d3f-7760-5cda-ac1c-eaa7d1162b82","slug":"human-thalassemia-rbc-glutathione-depletion","display_name":"Reduced glutathione depletion in human beta-thalassemic erythrocytes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Indicaxanthin 1-10 micromolar; cumene hydroperoxide challenge","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human beta-thalassemia donor erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ex vivo redox protection is not demonstrated oral treatment of anemia; preservation is not proof of increased glutathione synthesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human beta-thalassemia donor erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Added indicaxanthin delayed glutathione depletion during oxidative challenge of beta-thalassemic red cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. (2006). https://pubmed.ncbi.nlm.nih.gov/16984002/ DOI: 10.1080/10715760600554228","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Red blood cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cd2cc6e4-428a-5469-843d-314d09060dc7","evidence_kind":"source_excerpt","locator":"Lines 41-50","start_line":41,"end_line":50,"excerpt":"## indicaxanthin-rbc-glutathione\nAdded indicaxanthin delayed glutathione depletion during oxidative challenge of beta-thalassemic red cells.\nModel/species: Human beta-thalassemia donor erythrocytes\nTissue: Red blood cells\nExposure: Indicaxanthin 1-10 micromolar; cumene hydroperoxide challenge\nRoute: Ex vivo addition\nDuration: Not specified in accessed abstract\nLimits: Ex vivo redox protection is not demonstrated oral treatment of anemia; preservation is not proof of increased glutathione synthesis.\nPrimary reference: Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. (2006). https://pubmed.ncbi.nlm.nih.gov/16984002/ DOI: 10.1080/10715760600554228\nAccess: Primary PubMed abstract.","model_system":"Human beta-thalassemia donor erythrocytes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. 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