{"id":"2e1088da-4b9d-55e1-83fa-c2eb9424b173","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-human-insulin","predicate":"increases","statement":"Intravenous alanine significantly increased insulin secretion compared with saline in the study of 12 healthy men.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e7b0807f-c9ff-50af-9eaa-9f2967088c55","mechanism_event_label":"An alanine bolus can trigger insulin in humans.","subject":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"object":{"id":"4e2337ee-8956-52a7-9c05-e87e5924a665","slug":"human-iv-alanine-insulin","display_name":"Insulin response to intravenous alanine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e7b0807f-c9ff-50af-9eaa-9f2967088c55","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-human-insulin-event","event_type":"observed_relationship","label":"An alanine bolus can trigger insulin in humans.","description":"Intravenous alanine significantly increased insulin secretion compared with saline in the study of 12 healthy men.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4e2337ee-8956-52a7-9c05-e87e5924a665","slug":"human-iv-alanine-insulin","display_name":"Insulin response to intravenous alanine","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized crossover in 12 healthy men; equimolar IV amino-acid boluses on separate days after an overnight fast.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"IV exposure bypasses intestinal handling; no equivalent oral supplement effect is demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An alanine bolus can trigger insulin in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Intravenous Arginine Stimulates Glucagon Secretion More Than Equimolar Alanine, Leucine, Glutamine, and Proline in Humans. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40980546/ · DOI 10.1210/jendso/bvaf139","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4f3ebe0a-9f4a-5476-936d-dfc0704f0943","evidence_kind":"source_excerpt","locator":"Lines 328-334","start_line":328,"end_line":334,"excerpt":"## alanine-human-insulin\nAn alanine bolus can trigger insulin in humans.\nIntravenous alanine significantly increased insulin secretion compared with saline in the study of 12 healthy men.\nModel: Double-blind randomized crossover in 12 healthy men; equimolar IV amino-acid boluses on separate days after an overnight fast.\nLimitations: IV exposure bypasses intestinal handling; no equivalent oral supplement effect is demonstrated.\nEvidence access: Primary full text\nIntravenous Arginine Stimulates Glucagon Secretion More Than Equimolar Alanine, Leucine, Glutamine, and Proline in Humans. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40980546/ · DOI 10.1210/jendso/bvaf139","model_system":"Double-blind randomized crossover in 12 healthy men; equimolar IV amino-acid boluses on separate days after an overnight fast.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"01c5554c-a8ba-5c86-9b01-a0fa1a886cdb","stable_key":"import-10aa417f-4b03-599f-a453-4aa09edeb27c","title":"L-Alanine: carbon, nitrogen, protein synthesis and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8ce7dd76c88b2e25fa23d93f9655a244aadb9d90f55ec8b18ecf0fd4625a61d2","revision_id":"4ed32258-0213-599a-a272-6f8f62280773","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}