{"id":"2df89a64-068f-554e-b209-3c329fdbd951","stable_key":"research:trx1-inflammasome","predicate":"permits","statement":"The Trx1 system controls excessive ROS and permits NLRP3-dependent IL-1beta production in the tested Txnip-independent macrophage settings.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"context_dependent","is_public":true,"mechanism_event_id":"27a3292d-bec1-5f87-93d4-9e0182ee4f6f","mechanism_event_label":"An antioxidant system can enable an inflammatory response in some settings.","subject":{"id":"ca186ada-600c-5abd-ba01-d9d0784744e9","slug":"trx1-system","display_name":"thioredoxin-1 reducing system","entity_type_key":"cellular_process"},"object":{"id":"2c140313-fc97-5562-8225-97d3c22c0004","slug":"il1b-release","display_name":"IL-1beta production and release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"27a3292d-bec1-5f87-93d4-9e0182ee4f6f","stable_key":"research:trx1-inflammasome","event_type":"contextual_mechanism","label":"An antioxidant system can enable an inflammatory response in some settings.","description":"The Trx1 system controls excessive ROS and permits NLRP3-dependent IL-1beta production in the tested Txnip-independent macrophage settings.","status":"active","compartment":null,"participants":[{"entity":{"id":"ca186ada-600c-5abd-ba01-d9d0784744e9","slug":"trx1-system","display_name":"thioredoxin-1 reducing system","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2c140313-fc97-5562-8225-97d3c22c0004","slug":"il1b-release","display_name":"IL-1beta production and release","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"Macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse macrophage gene perturbation/inflammasome experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specific lineage/stimuli; not a universal dietary selenium effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"04fc88a7-1a73-59fc-9ea4-040e77d52445","evidence_kind":"curated_literature_summary","locator":"lines 1372-1382","start_line":1372,"end_line":1382,"excerpt":"## trx1-inflammasome\n\nAn antioxidant system can enable an inflammatory response in some settings.\n\nThe Trx1 system controls excessive ROS and permits NLRP3-dependent IL-1beta production in the tested Txnip-independent macrophage settings.\n\nOrganism: Mus musculus\nCell type: Macrophages\nExperimental model: Mouse macrophage gene perturbation/inflammasome experiments\nLimitations: Specific lineage/stimuli; not a universal dietary selenium effect.\nPrimary reference: [Thioredoxin-1 distinctly promotes NF-kB target DNA binding and NLRP3 inflammasome activation independently of Txnip](https://elifesciences.org/articles/53627)","model_system":"Mouse macrophage gene perturbation/inflammasome experiments","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[{"id":"c4c894cb-324f-54d9-8f8d-d82fad4c8442","title":"TXNIP–NLRP3 is not a universal selenium-controlled switch","kind":"context_difference","status":"qualified","why":"TXNIP involvement in one setting coexists with Txnip-independent macrophage IL-1beta requiring Trx1 in another.","resolution":"Record stimulus, lineage and perturbation; do not automatically reverse TrxR1 loss into increased IL-1beta.","created_at":"2026-09-17 07:19:34","record_type":"qualification","display_label":"Source qualification","record_url":"/corrections/c4c894cb-324f-54d9-8f8d-d82fad4c8442","literature_review":{"revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1646,"end_line":1652,"papers":[{"paper_key":"zhou-2010","title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","url":"https://pubmed.ncbi.nlm.nih.gov/20023662/","doi":"10.1038/ni.1831","year":2010,"model":"Cellular and mouse metabolic/oxidative-stress models","summary":"Supports context-specific TXNIP/NLRP3 link."},{"paper_key":"muri-2020","title":"Thioredoxin-1 distinctly promotes NF-kB target DNA binding and NLRP3 inflammasome activation independently of Txnip","url":"https://elifesciences.org/articles/53627","doi":"10.7554/eLife.53627","year":2020,"model":"Mouse macrophage gene perturbation/inflammasome experiments","summary":"Txnip-independent IL-1beta production can require Trx1 control of excessive ROS."}]},"sides":[{"conflict_id":"c4c894cb-324f-54d9-8f8d-d82fad4c8442","ordinal":0,"label":"Original preserved statement","revision_id":"fbed30e0-1c0d-5b83-8a1f-2867fbe8a5b5","start_line":244,"end_line":248,"quote":"TrxR1 (SELENOENZYME) keeps Trx1 reduced → keeps TXNIP sequestered → NLRP3 OFF\n\n```\n\n**Selenium deficiency → oxidized Trx1 → TXNIP released → IL-1β.** One selenoenzyme standing between redox state and the master inflammatory cytokine.","claim_id":null,"source_key":"immune","source_title":"Selenium in immune cells","claim_ids":[]},{"conflict_id":"c4c894cb-324f-54d9-8f8d-d82fad4c8442","ordinal":1,"label":"Original preserved statement","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","start_line":388,"end_line":394,"quote":"Macrophage / inflammasome signaling\n\nThioredoxin, TXNIP, lipid peroxide and eicosanoid pathways provide plausible mechanisms\n\nCell/animal\n\nA useful summary is: selenium status can alter immune redox tone and cell survival, but no single immune-cell cascade explains all reported supplementation effects.","claim_id":null,"source_key":"deficiency","source_title":"Selenium deficiency: a mechanism-first reference","claim_ids":[]},{"conflict_id":"c4c894cb-324f-54d9-8f8d-d82fad4c8442","ordinal":2,"label":"Literature correction and experimental limits","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1646,"end_line":1652,"quote":"## TXNIP–NLRP3 is not a universal selenium-controlled switch\n\nTXNIP involvement in one setting coexists with Txnip-independent macrophage IL-1beta requiring Trx1 in another.\n\nRecord stimulus, lineage and perturbation; do not automatically reverse TrxR1 loss into increased IL-1beta.\nPrimary reference: [Thioredoxin-interacting protein links oxidative stress to inflammasome activation](https://pubmed.ncbi.nlm.nih.gov/20023662/)\nPrimary reference: [Thioredoxin-1 distinctly promotes NF-kB target DNA binding and NLRP3 inflammasome activation independently of Txnip](https://elifesciences.org/articles/53627)","claim_id":null,"source_key":"selenium-research-2026-09-17","source_title":"Selenium: literature corrections and mechanism additions","claim_ids":[]}]}],"research":{"topic":"Selenium scientific audit","plain_language":"An antioxidant system can enable an inflammatory response in some settings.","evidence_scope":"direct_experimental","papers":[{"key":"muri-2020","title":"Thioredoxin-1 distinctly promotes NF-kB target DNA binding and NLRP3 inflammasome activation independently of Txnip","url":"https://elifesciences.org/articles/53627","doi":"10.7554/eLife.53627","year":2020,"model":"Mouse macrophage gene perturbation/inflammasome experiments","summary":"Txnip-independent IL-1beta production can require Trx1 control of excessive ROS."}]}}