{"id":"2dcd2e4b-f7c6-5833-9017-7a114451c787","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-apob-2011","predicate":"reduces","statement":"The same trial reported a 4 mg/dL (5%) apolipoprotein B reduction from baseline at week 16 and a significant comparison with placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9da26296-ee0f-554e-9c5f-e02a87ab4b0e","mechanism_event_label":"A related lipoprotein marker also decreased modestly.","subject":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"object":{"id":"f746a287-c8a1-52d8-b477-fd4df2e1a70f","slug":"circulating-apolipoprotein-b-concentration","display_name":"Circulating apolipoprotein B concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9da26296-ee0f-554e-9c5f-e02a87ab4b0e","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-pantethine-apob-2011-event","event_type":"observed_intervention","label":"A related lipoprotein marker also decreased modestly.","description":"The same trial reported a 4 mg/dL (5%) apolipoprotein B reduction from baseline at week 16 and a significant comparison with placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0600873-c581-5429-91cb-414f179823ce","slug":"pantethine","display_name":"Pantethine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f746a287-c8a1-52d8-b477-fd4df2e1a70f","slug":"circulating-apolipoprotein-b-concentration","display_name":"Circulating apolipoprotein B concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized triple-blind placebo-controlled 16-week trial in 120 adults at low-to-moderate cardiovascular risk","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"TLC diet begun four weeks before randomization and continued; 60 per group; pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Lipid markers rather than cardiovascular events; pantethine is a derivative, not dietary B5 repletion. Absolute changes were small. Industry-associated authors; full methods were not retrieved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A related lipoprotein marker also decreased modestly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-rumberger2011] Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. (2011). https://pubmed.ncbi.nlm.nih.gov/21925346/ DOI: 10.1016/j.nutres.2011.08.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating lipids and lipoproteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"68dec8c8-b545-5cfc-8914-1a9006204f6e","evidence_kind":"source_excerpt","locator":"Lines 1397-1409","start_line":1397,"end_line":1409,"excerpt":"### b5-clin-pantethine-apob-2011\nThe same trial reported a 4 mg/dL (5%) apolipoprotein B reduction from baseline at week 16 and a significant comparison with placebo.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A related lipoprotein marker also decreased modestly.\norganism: Homo sapiens\ntissue_or_cell_type: Circulating lipids and lipoproteins\nexperimental_model: Randomized triple-blind placebo-controlled 16-week trial in 120 adults at low-to-moderate cardiovascular risk\nlimitations: Lipid markers rather than cardiovascular events; pantethine is a derivative, not dietary B5 repletion. Absolute changes were small. Industry-associated authors; full methods were not retrieved.\nexposure: TLC diet begun four weeks before randomization and continued; 60 per group; pantethine 600 mg/day for weeks 1–8 and 900 mg/day for weeks 9–16.\ncross_nutrient: false\nevidence_location: Primary indexed abstract.\n[b5-clin-rumberger2011] Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. (2011). https://pubmed.ncbi.nlm.nih.gov/21925346/ DOI: 10.1016/j.nutres.2011.08.001","model_system":"Randomized triple-blind placebo-controlled 16-week trial in 120 adults at low-to-moderate cardiovascular risk","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-rumberger2011] Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. (2011). https://pubmed.ncbi.nlm.nih.gov/21925346/ DOI: 10.1016/j.nutres.2011.08.001","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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