{"id":"2d62adb8-c224-509e-a0a4-dd53a4dc377c","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taut-beta-alanine","predicate":"shares_binding_site_with","statement":"Human TauT structures captured beta-alanine and taurine as separately bound substrate analogues at the transporter binding site.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b9c61dab-c331-5f10-8890-b8fc2345c36a","mechanism_event_label":"Beta-alanine and taurine interact with the same molecular doorway.","subject":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"object":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b9c61dab-c331-5f10-8890-b8fc2345c36a","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-taut-beta-alanine-event","event_type":"observed_relationship","label":"Beta-alanine and taurine interact with the same molecular doorway.","description":"Human TauT structures captured beta-alanine and taurine as separately bound substrate analogues at the transporter binding site.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c00b89ac-1c32-5d7d-aec4-490af879460a","slug":"slc6a6","display_name":"Human taurine transporter / SLC6A6","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human SLC6A6 cryo-EM structures and biochemical analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Shared binding does not prove taurine depletion at typical beta-alanine supplement exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Beta-alanine and taurine interact with the same molecular doorway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Molecular basis of human taurine transporter uptake and inhibition. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40789850/ · DOI 10.1038/s41467-025-62857-w","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"26faa5bb-63fa-5df3-bc02-3c7504a1da31","evidence_kind":"source_excerpt","locator":"Lines 129-135","start_line":129,"end_line":135,"excerpt":"## taurine-taut-beta-alanine\nBeta-alanine and taurine interact with the same molecular doorway.\nHuman TauT structures captured beta-alanine and taurine as separately bound substrate analogues at the transporter binding site.\nModel: Human SLC6A6 cryo-EM structures and biochemical analysis.\nLimitations: Shared binding does not prove taurine depletion at typical beta-alanine supplement exposure.\nEvidence access: Primary abstract\nMolecular basis of human taurine transporter uptake and inhibition. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40789850/ · DOI 10.1038/s41467-025-62857-w","model_system":"Human SLC6A6 cryo-EM structures and biochemical analysis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}