{"id":"2d3ebcaf-a5e7-5aff-8f65-c72c5a795d5b","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-free-testosterone","predicate":"increases","statement":"Mean free testosterone increased at the one-week morning measurement in the eight-man supplementation study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"23b01445-f40d-524b-a4c4-cafb8ecebf7d","mechanism_event_label":"A short uncontrolled comparison reported a rise in free testosterone; it is not reliable evidence of a general testosterone-boosting effect.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"e78f545c-d4f7-53a4-b575-56c8fdb8b470","slug":"circulating-free-testosterone","display_name":"Circulating free testosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"23b01445-f40d-524b-a4c4-cafb8ecebf7d","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-short-study-free-testosterone-event","event_type":"observed_intervention","label":"A short uncontrolled comparison reported a rise in free testosterone; it is not reliable evidence of a general testosterone-boosting effect.","description":"Mean free testosterone increased at the one-week morning measurement in the eight-man supplementation study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e78f545c-d4f7-53a4-b575-56c8fdb8b470","slug":"circulating-free-testosterone","display_name":"Circulating free testosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sequential placebo-day and supplementation observations in eight men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"10 mg boron/day for one week; acute six-hour and day-seven measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eight participants without a randomized parallel control. 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Lower SHBG does not demonstrate direct boron binding to SHBG.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human healthy male volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A short uncontrolled comparison reported a rise in free testosterone; it is not reliable evidence of a general testosterone-boosting effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma hormones and inflammatory biomarkers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b0a0b556-af0c-5744-a643-9a23c1835ad5","evidence_kind":"source_excerpt","locator":"Lines 1015-1026","start_line":1015,"end_line":1026,"excerpt":"### boron-short-study-free-testosterone\nMean free testosterone increased at the one-week morning measurement in the eight-man supplementation study.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A short uncontrolled comparison reported a rise in free testosterone; it is not reliable evidence of a general testosterone-boosting effect.\norganism: Human healthy male volunteers\ntissue_or_cell_type: Plasma hormones and inflammatory biomarkers\nexperimental_model: Sequential placebo-day and supplementation observations in eight men\nlimitations: Eight participants without a randomized parallel control. Time effects, short duration and multiple endpoints limit causal and clinical interpretation. Lower SHBG does not demonstrate direct boron binding to SHBG.\nexposure: 10 mg boron/day for one week; acute six-hour and day-seven measurements\nevidence_span: {\"source_cache\": \"artifacts/boron-research/21129941.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\", \"start_char\": 0, \"end_char\": 1706, \"text_sha256\": \"4e5892df5d6f2cf5e87f6bd3c7c12dae16cc2fa2517d5a81267b810175485157\"}\n[boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","model_system":"Sequential placebo-day and supplementation observations in eight men","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p21129941] Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. (2011). https://pubmed.ncbi.nlm.nih.gov/21129941/ DOI: 10.1016/j.jtemb.2010.10.001","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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