{"id":"2cd8e07e-df24-5782-8ce2-62e0b25cb5ad","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-met-rat-diet-coa-preserved","predicate":"dietary_deprivation_does_not_lower","statement":"Rats fed the pantothenate-deficient diet retained control-level tissue CoA despite more than 90% lower pantothenate in heart, kidney, gastrocnemius and testes and about 70% lower liver pantothenate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"55525355-f3b8-5ad4-b3a8-d7df304b01cb","mechanism_event_label":"Large drops in tissue B5 did not necessarily deplete the measured CoA pool in this rat experiment.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"55525355-f3b8-5ad4-b3a8-d7df304b01cb","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-met-rat-diet-coa-preserved-event","event_type":"biochemical_relationship","label":"Large drops in tissue B5 did not necessarily deplete the measured CoA pool in this rat experiment.","description":"Rats fed the pantothenate-deficient diet retained control-level tissue CoA despite more than 90% lower pantothenate in heart, kidney, gastrocnemius and testes and about 70% lower liver pantothenate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary abstract, first four sentences","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat pantothenate-deficient versus regular-diet feeding experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Pantothenic-acid-deficient diet; concentration and feeding duration unavailable in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole-tissue CoA measurement does not establish unchanged subcellular pools or flux. Growth was impaired, so maintained CoA did not show nutritional adequacy. Different tissues/models from the tumor study do not constitute a same-context contradiction. This experiment does not establish a dietary pantothenate threshold or benefit from B5 supplementation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Large drops in tissue B5 did not necessarily deplete the measured CoA pool in this rat experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-met-rat1982] Coenzyme A metabolism in pantothenic acid-deficient rats. (1982). https://pubmed.ncbi.nlm.nih.gov/7086543/ DOI: 10.1093/jn/112.6.1144","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Heart, kidney, gastrocnemius, testes and liver","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b6db9f40-8e80-56c0-82a2-e87b44ab9370","evidence_kind":"source_excerpt","locator":"Lines 1131-1143","start_line":1131,"end_line":1143,"excerpt":"### b5-met-rat-diet-coa-preserved\nRats fed the pantothenate-deficient diet retained control-level tissue CoA despite more than 90% lower pantothenate in heart, kidney, gastrocnemius and testes and about 70% lower liver pantothenate.\nCondition category: nutrient_deficiency\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Large drops in tissue B5 did not necessarily deplete the measured CoA pool in this rat experiment.\norganism: Rattus norvegicus\ntissue_or_cell_type: Heart, kidney, gastrocnemius, testes and liver\nexperimental_model: Rat pantothenate-deficient versus regular-diet feeding experiment\nlimitations: Whole-tissue CoA measurement does not establish unchanged subcellular pools or flux. Growth was impaired, so maintained CoA did not show nutritional adequacy. Different tissues/models from the tumor study do not constitute a same-context contradiction. This experiment does not establish a dietary pantothenate threshold or benefit from B5 supplementation.\nexposure: Pantothenic-acid-deficient diet; concentration and feeding duration unavailable in the abstract.\ncross_nutrient: false\nevidence_location: Primary abstract, first four sentences\n[b5-met-rat1982] Coenzyme A metabolism in pantothenic acid-deficient rats. (1982). https://pubmed.ncbi.nlm.nih.gov/7086543/ DOI: 10.1093/jn/112.6.1144","model_system":"Rat pantothenate-deficient versus regular-diet feeding experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-met-rat1982] Coenzyme A metabolism in pantothenic acid-deficient rats. (1982). https://pubmed.ncbi.nlm.nih.gov/7086543/ DOI: 10.1093/jn/112.6.1144","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}