{"id":"2cac89ab-b7be-5b74-8f69-3a58fbd4a4be","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-mixture-components","predicate":"contains_redox_contributors_to","statement":"The authors attributed additional extract activity to constituents including ascorbate and glutathione.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"346f9292-2461-508e-aff9-474a3b891c4e","mechanism_event_label":"The extract result cannot be assigned entirely to nasunin.","subject":{"id":"875a1f17-9341-5757-bc5d-6270e7619668","slug":"nasunin-rich-peel-extract","display_name":"Nasunin-rich semi-purified eggplant peel extract","entity_type_key":"chemical_species"},"object":{"id":"5fc9289b-6e14-57f5-ae6a-0d2bc843eaec","slug":"nasunin-extract-antioxidant-response","display_name":"Antioxidant response of nasunin-rich peel preparations","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"346f9292-2461-508e-aff9-474a3b891c4e","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-mixture-components-event","event_type":"biochemical_relationship","label":"The extract result cannot be assigned entirely to nasunin.","description":"The authors attributed additional extract activity to constituents including ascorbate and glutathione.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38d0c4d9-53d1-5239-bfe3-c1b5e9b79085","slug":"ascorbate","display_name":"L-Ascorbate","entity_type_key":"small_molecule"},"role":"measured_extract_constituent","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"measured_extract_constituent","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"875a1f17-9341-5757-bc5d-6270e7619668","slug":"nasunin-rich-peel-extract","display_name":"Nasunin-rich semi-purified eggplant peel extract","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5fc9289b-6e14-57f5-ae6a-0d2bc843eaec","slug":"nasunin-extract-antioxidant-response","display_name":"Antioxidant response of nasunin-rich peel preparations","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/extract2016.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"59f579b08c2eb270f935d58dfb0a751867b624b099b5eea3674abc1bb8ec0115\", \"start_char\": 0, \"end_char\": 1165, \"text_sha256\": \"59f579b08c2eb270f935d58dfb0a751867b624b099b5eea3674abc1bb8ec0115\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified crystals versus semi-purified extracts in EPR and neutrophil assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chlorogenic-acid-depleted extracts; purified NAS and D3R comparisons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mixture composition does not demonstrate pharmacological synergy. Human cells outside the body are not a clinical trial; assays differ from colon-cell ROS experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cell-free assays and isolated human neutrophils","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The extract result cannot be assigned entirely to nasunin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-pextract2016] Characterization and antioxidant activity of semi-purified extracts and pure delphinidin-glycosides from eggplant peel ( Solanum melongena L.) 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Human cells outside the body are not a clinical trial; assays differ from colon-cell ROS experiments.\nexposure: Chlorogenic-acid-depleted extracts; purified NAS and D3R comparisons\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/extract2016.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"59f579b08c2eb270f935d58dfb0a751867b624b099b5eea3674abc1bb8ec0115\", \"start_char\": 0, \"end_char\": 1165, \"text_sha256\": \"59f579b08c2eb270f935d58dfb0a751867b624b099b5eea3674abc1bb8ec0115\"}\n[nasunin-pextract2016] Characterization and antioxidant activity of semi-purified extracts and pure delphinidin-glycosides from eggplant peel ( Solanum melongena L.) 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