{"id":"2ca8e6bf-76a4-5bbe-be59-ad4649dff110","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-bortezomib-vitc","predicate":"no_detected_antagonism","statement":"Oral vitamin C at 40 or 500 mg/kg did not antagonize bortezomib in the same mouse experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"06800a09-6954-52ca-9ea7-af72fb3a9557","mechanism_event_label":"Another nutrient comparator did not reproduce high-EGCG antagonism.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"23cac268-8b53-561d-beca-8d463a2ab64a","slug":"bortezomib-antitumor-effect","display_name":"Antitumor activity of bortezomib in specified models","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"06800a09-6954-52ca-9ea7-af72fb3a9557","stable_key":"ec987f3e-0b3c-55cc-b304-c703a738e35d:egcg-bortezomib-vitc-event","event_type":"observed_relationship","label":"Another nutrient comparator did not reproduce high-EGCG antagonism.","description":"Oral vitamin C at 40 or 500 mg/kg did not antagonize bortezomib in the same mouse experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"23cac268-8b53-561d-beca-8d463a2ab64a","slug":"bortezomib-antitumor-effect","display_name":"Antitumor activity of bortezomib in specified models","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7c75470d-e9e0-5a6b-b342-6a1201da6b13","slug":"bortezomib","display_name":"Bortezomib","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"CWR22 xenograft model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Species, route and exposure matter; this comparison does not justify combining supplements with cancer treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"EGCG collection; comparator and shared-pathway records retain their actual intervention.","comparator":null,"unit":null,"notes":"","entity":{"slug":"egcg","display_name":"Epigallocatechin-3-gallate (EGCG)","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Another nutrient comparator did not reproduce high-EGCG antagonism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21400028/ · DOI 10.1007/s00280-011-1591-2","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3c268fcc-9242-5f4b-b647-75a9e6990af0","evidence_kind":"source_excerpt","locator":"Lines 444-450","start_line":444,"end_line":450,"excerpt":"## egcg-bortezomib-vitc\nAnother nutrient comparator did not reproduce high-EGCG antagonism.\nOral vitamin C at 40 or 500 mg/kg did not antagonize bortezomib in the same mouse experiment.\nModel: CWR22 xenograft model.\nLimitations: Species, route and exposure matter; this comparison does not justify combining supplements with cancer treatment.\nEvidence access: primary abstract.\nPreclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21400028/ · DOI 10.1007/s00280-011-1591-2","model_system":"CWR22 xenograft model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Primary-abstract paraphrase; no full-text methods verification claimed.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1f6d09e8-3aae-5c41-9ea7-15d0d1cab72d","stable_key":"import-ec987f3e-0b3c-55cc-b304-c703a738e35d","title":"EGCG: receptor signaling, metabolism, nutrient interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b101c8d4d96ee03ff97eb1922c7bb0f96943295af473fdc3ef98b0dbd62fe8c7","revision_id":"e19bc5b2-ee3c-5f67-b5c5-9dc3b7d5f850","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}