{"id":"2ca6e631-a98c-59a5-97a1-81d9fe8d74db","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-rat-calcium","predicate":"inhibits","statement":"Stevioside relaxed vasopressin-contracted rat aortic rings and inhibited calcium influx in A7r5 smooth-muscle cells; the relaxation disappeared in calcium-free medium.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b232b93d-56cd-50d6-ab05-cff7140d57dd","mechanism_event_label":"A vascular calcium-entry effect differs from pancreatic calcium-signal potentiation.","subject":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"object":{"id":"3f845b7c-884b-5fb3-b187-6d4f775514f0","slug":"rat-vascular-calcium-influx-stevioside","display_name":"Rat vascular calcium influx during stevioside exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b232b93d-56cd-50d6-ab05-cff7140d57dd","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-rat-calcium-event","event_type":"observed_relationship","label":"A vascular calcium-entry effect differs from pancreatic calcium-signal potentiation.","description":"Stevioside relaxed vasopressin-contracted rat aortic rings and inhibited calcium influx in A7r5 smooth-muscle cells; the relaxation disappeared in calcium-free medium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3f845b7c-884b-5fb3-b187-6d4f775514f0","slug":"rat-vascular-calcium-influx-stevioside","display_name":"Rat vascular calcium influx during stevioside exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat aorta with and without endothelium; cultured rat A7r5 cells; intraperitoneal 25 mg/kg also examined in hypertensive rats.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The specific calcium-channel molecular target was not established in the accessed abstract; parenteral dosing is not oral sweetener use.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A vascular calcium-entry effect differs from pancreatic calcium-signal potentiation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibitory effect of stevioside on calcium influx to produce antihypertension. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11745013/ · DOI 10.1055/s-2001-18841","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"934486cd-f0e2-52eb-ad07-aa501c447346","evidence_kind":"source_excerpt","locator":"Lines 290-296","start_line":290,"end_line":296,"excerpt":"## stevia-rat-calcium\nA vascular calcium-entry effect differs from pancreatic calcium-signal potentiation.\nStevioside relaxed vasopressin-contracted rat aortic rings and inhibited calcium influx in A7r5 smooth-muscle cells; the relaxation disappeared in calcium-free medium.\nModel: Rat aorta with and without endothelium; cultured rat A7r5 cells; intraperitoneal 25 mg/kg also examined in hypertensive rats.\nLimitations: The specific calcium-channel molecular target was not established in the accessed abstract; parenteral dosing is not oral sweetener use.\nEvidence access: Primary abstract\nInhibitory effect of stevioside on calcium influx to produce antihypertension. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11745013/ · DOI 10.1055/s-2001-18841","model_system":"Rat aorta with and without endothelium; cultured rat A7r5 cells; intraperitoneal 25 mg/kg also examined in hypertensive rats.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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