{"id":"2ca000ec-0ff9-5b3c-a8f9-144402192817","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-carrier-interpretation","predicate":"may_reflect_carrier_changes_rather_than","statement":"The authors proposed that lower plasma CoQ could reflect loss of lipoprotein carriers rather than a statin-specific depletion mechanism.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3394ad84-f024-59f7-aa16-e1ea162bf546","mechanism_event_label":"Blood transport and intracellular deficiency are different explanations to test.","subject":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"object":{"id":"3bee7141-e6c1-567b-b24a-26810012cdd5","slug":"coq-cellular-concentration","display_name":"Cellular coenzyme Q concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3394ad84-f024-59f7-aa16-e1ea162bf546","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-statin-carrier-interpretation-event","event_type":"biochemical_relationship","label":"Blood transport and intracellular deficiency are different explanations to test.","description":"The authors proposed that lower plasma CoQ could reflect loss of lipoprotein carriers rather than a statin-specific depletion mechanism.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9c47a458-6bce-5886-bbd3-dfe38a7ec6e9","slug":"coq-plasma-concentration","display_name":"Plasma coenzyme Q10 concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3bee7141-e6c1-567b-b24a-26810012cdd5","slug":"coq-cellular-concentration","display_name":"Cellular coenzyme Q concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/16872244.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\", \"start_char\": 0, \"end_char\": 2245, \"text_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized three-arm parallel study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Simvastatin 40 mg/day, ezetimibe 10 mg/day or both for 14 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Plasma measurements and correlation; neither tissue CoQ nor mitochondrial dysfunction was demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"72 healthy men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Blood transport and intracellular deficiency are different explanations to test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p16872244] Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. (2006). https://pubmed.ncbi.nlm.nih.gov/16872244/ DOI: 10.2165/00002018-200629080-00007","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma CoQ and lipoprotein concentrations","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"698de769-2b93-5a83-aa4a-947303e50bd2","evidence_kind":"source_excerpt","locator":"Lines 944-955","start_line":944,"end_line":955,"excerpt":"### coq10-statin-carrier-interpretation\nThe authors proposed that lower plasma CoQ could reflect loss of lipoprotein carriers rather than a statin-specific depletion mechanism.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Blood transport and intracellular deficiency are different explanations to test.\norganism: 72 healthy men\ntissue_or_cell_type: Plasma CoQ and lipoprotein concentrations\nexperimental_model: Randomized three-arm parallel study\nlimitations: Plasma measurements and correlation; neither tissue CoQ nor mitochondrial dysfunction was demonstrated.\nexposure: Simvastatin 40 mg/day, ezetimibe 10 mg/day or both for 14 days\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/16872244.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\", \"start_char\": 0, \"end_char\": 2245, \"text_sha256\": \"65abd11b5f58ce1125f554d52ed5203575d7a3ba0d20b789abce16148f3b5e27\"}\n[coq10-p16872244] Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial. 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