{"id":"2c9c6404-7cc9-564a-88ae-165cc6f4464f","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-mci-2026-primary-null","predicate":"no_significant_coprimary_benefit","statement":"None of six coprimary outcomes met the prespecified significance threshold in the 2026 low-dose lithium trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"78ee5fb1-c7df-5a60-9e55-91db52dd78c1","mechanism_event_label":"The newer pilot did not confirm its primary efficacy hypotheses.","subject":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"object":{"id":"cd0c3be5-4e16-5b9c-930e-0894ec585dc7","slug":"human-mci-lithium-cognition","display_name":"Human MCI cognitive/functional outcomes during lithium trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"78ee5fb1-c7df-5a60-9e55-91db52dd78c1","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-mci-2026-primary-null-event","event_type":"observed_relationship","label":"The newer pilot did not confirm its primary efficacy hypotheses.","description":"None of six coprimary outcomes met the prespecified significance threshold in the 2026 low-dose lithium trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bb5db13c-d287-5847-93b2-98ab0d023797","slug":"lithium-carbonate","display_name":"Lithium carbonate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cd0c3be5-4e16-5b9c-930e-0894ec585dc7","slug":"human-mci-lithium-cognition","display_name":"Human MCI cognitive/functional outcomes during lithium trials","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"NCT03185208; 83 randomized, 80 started; two years; prespecified P<.01.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Verbal-recall difference P=.05 and exploratory amyloid subgroups are not positive primary results.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The newer pilot did not confirm its primary efficacy hypotheses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41770546/ · DOI 10.1001/jamaneurol.2026.0072","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d5c0d37c-45bf-5f97-abdc-e439f18f545a","evidence_kind":"source_excerpt","locator":"Lines 536-542","start_line":536,"end_line":542,"excerpt":"## lithium-mci-2026-primary-null\nThe newer pilot did not confirm its primary efficacy hypotheses.\nNone of six coprimary outcomes met the prespecified significance threshold in the 2026 low-dose lithium trial.\nModel: NCT03185208; 83 randomized, 80 started; two years; prespecified P<.01.\nLimitations: Verbal-recall difference P=.05 and exploratory amyloid subgroups are not positive primary results.\nEvidence access: Primary full text\nLow-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41770546/ · DOI 10.1001/jamaneurol.2026.0072","model_system":"NCT03185208; 83 randomized, 80 started; two years; prespecified P<.01.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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