{"id":"2c45a785-eee7-5ee8-8a48-bebced9a427a","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ltp","predicate":"enhances_tested","statement":"Ddo deletion or oral D-aspartate elevation enhanced hippocampal LTP without improving cognitive flexibility in the reported mouse experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b57a5ae7-1423-5bf8-8d9b-662404e53bae","mechanism_event_label":"A stronger synaptic-plasticity signal did not translate into a general cognitive advantage.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"a2631b7b-cc4d-5cd8-86f8-28367f7d95b2","slug":"mouse-hippocampal-ltp","display_name":"Mouse hippocampal long-term potentiation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b57a5ae7-1423-5bf8-8d9b-662404e53bae","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ltp-event","event_type":"observed_relationship","label":"A stronger synaptic-plasticity signal did not translate into a general cognitive advantage.","description":"Ddo deletion or oral D-aspartate elevation enhanced hippocampal LTP without improving cognitive flexibility in the reported mouse experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a2631b7b-cc4d-5cd8-86f8-28367f7d95b2","slug":"mouse-hippocampal-ltp","display_name":"Mouse hippocampal long-term potentiation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"0dfaac36-ded6-5591-bacc-aef6e58b1135","slug":"mouse-nmda-receptors","display_name":"Mouse NMDA-type receptors, subunits unresolved","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse genetic and oral-exposure models; slices and behavioral tests.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"LTP is not synonymous with better memory; oral dose not specified in accessed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A stronger synaptic-plasticity signal did not translate into a general cognitive advantage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Increased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. · 2008 · https://pubmed.ncbi.nlm.nih.gov/17981050/ · DOI 10.1016/j.mcn.2007.09.012","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"efd31a3c-879f-57b9-b667-8efbf5617967","evidence_kind":"source_excerpt","locator":"Lines 240-246","start_line":240,"end_line":246,"excerpt":"## d-aspartate-ltp\nA stronger synaptic-plasticity signal did not translate into a general cognitive advantage.\nDdo deletion or oral D-aspartate elevation enhanced hippocampal LTP without improving cognitive flexibility in the reported mouse experiments.\nModel: Mouse genetic and oral-exposure models; slices and behavioral tests.\nLimitations: LTP is not synonymous with better memory; oral dose not specified in accessed abstract.\nEvidence access: Primary abstract\nIncreased levels of d-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility. · 2008 · https://pubmed.ncbi.nlm.nih.gov/17981050/ · DOI 10.1016/j.mcn.2007.09.012","model_system":"Mouse genetic and oral-exposure models; slices and behavioral tests.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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