{"id":"2c2d558f-048a-57c5-a02f-c5de4406730c","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-d2d-diabetes","predicate":"does-not-significantly-reduce-in-this-trial","statement":"Diabetes developed in 293 D3 recipients and 323 placebo recipients; HR0.88 (95% CI0.75–1.04; P=0.12).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ee06adc7-d030-5b48-963f-bbae5e8e5fa9","mechanism_event_label":"This individual D3 trial did not meet statistical significance for preventing diabetes.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"6055bc93-5c97-50e4-8b6f-9ca9b488fa8f","slug":"type-2-diabetes-incidence","display_name":"Incidence of type 2 diabetes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ee06adc7-d030-5b48-963f-bbae5e8e5fa9","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-d2d-diabetes-event","event_type":"observed_intervention","label":"This individual D3 trial did not meet statistical significance for preventing diabetes.","description":"Diabetes developed in 293 D3 recipients and 323 placebo recipients; HR0.88 (95% CI0.75–1.04; P=0.12).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6055bc93-5c97-50e4-8b6f-9ca9b488fa8f","slug":"type-2-diabetes-incidence","display_name":"Incidence of type 2 diabetes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"D2 d randomized trial; 2423 adults with prediabetes; median 2.5 years","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"D3 4000 IU/day versus placebo; participants met≥ 2 of 3 prediabetes criteria.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Individual-trial estimate is compatible with modest benefit and no effect; not a claim that pooled prevention evidence is negative.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This individual D3 trial did not meet statistical significance for preventing diabetes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pittas2019] Vitamin D Supplementation and Prevention of Type 2 Diabetes. (2019). https://pubmed.ncbi.nlm.nih.gov/31173679/ DOI: 10.1056/nejmoa1900906","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical glucose outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"18f155ce-2552-5e10-b758-b10d51519ad5","evidence_kind":"source_excerpt","locator":"Lines 1639-1650","start_line":1639,"end_line":1650,"excerpt":"### vd-d2d-diabetes\nDiabetes developed in 293 D3 recipients and 323 placebo recipients; HR0.88 (95% CI0.75–1.04; P=0.12).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This individual D3 trial did not meet statistical significance for preventing diabetes.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical glucose outcomes\nexperimental_model: D2 d randomized trial; 2423 adults with prediabetes; median 2.5 years\nlimitations: Individual-trial estimate is compatible with modest benefit and no effect; not a claim that pooled prevention evidence is negative.\nexposure: D3 4000 IU/day versus placebo; participants met≥ 2 of 3 prediabetes criteria.\ncross_nutrient: false\n[pittas2019] Vitamin D Supplementation and Prevention of Type 2 Diabetes. 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