{"id":"2c127690-2004-5202-9c28-dc956b5f55f7","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-exercise","predicate":"attenuates","statement":"Zinc-carnosine reduced the exercise-associated permeability rise after fourteen days; combined colostrum treatment also showed an earlier response.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d472bb2c-bbec-5c8e-a912-d3e8b54c8bff","mechanism_event_label":"A separate challenge model showed a barrier-marker effect.","subject":{"id":"a1ed4282-d9fa-5acb-94f3-d4cf19dfd693","slug":"zinc-carnosine","display_name":"Zinc L-carnosine complex / polaprezinc","entity_type_key":"chemical_species"},"object":{"id":"63028c06-52c5-5481-80c6-15d2bd81ee2f","slug":"human-exercise-intestinal-permeability","display_name":"Human exercise-associated intestinal permeability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d472bb2c-bbec-5c8e-a912-d3e8b54c8bff","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-zinc-exercise-event","event_type":"observed_relationship","label":"A separate challenge model showed a barrier-marker effect.","description":"Zinc-carnosine reduced the exercise-associated permeability rise after fourteen days; 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does not establish prevention of heat stroke.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A separate challenge model showed a barrier-marker effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27357095/ · DOI 10.3945/ajcn.116.134403","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ed7a814e-d696-5221-ad6f-06147a5f40df","evidence_kind":"source_excerpt","locator":"Lines 380-386","start_line":380,"end_line":386,"excerpt":"## carnosine-zinc-exercise\nA separate challenge model showed a barrier-marker effect.\nZinc-carnosine reduced the exercise-associated permeability rise after fourteen days; combined colostrum treatment also showed an earlier response.\nModel: Eight-person four-arm crossover trial.\nLimitations: Small study; does not establish prevention of heat stroke.\nEvidence access: Primary abstract\nZinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27357095/ · DOI 10.3945/ajcn.116.134403","model_system":"Eight-person four-arm crossover trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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