{"id":"2c11dbab-4785-5873-814b-9bbb270676c1","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-yars-c-domain","predicate":"promotes","statement":"A heptapeptide from the human YARS1 C-domain induced chemotaxis of mononuclear phagocytes and polymorphonuclear leukocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b2848171-b9c5-5077-95e1-9ca11d4eb56d","mechanism_event_label":"A different part of the same protein has another signaling activity.","subject":{"id":"12bddc89-7e35-5f30-8407-9039646ae9a4","slug":"human-yars1-c-terminal-fragment","display_name":"Human YARS1 C-terminal EMAPII-like fragment","entity_type_key":"protein"},"object":{"id":"51c668a9-1361-52af-b9e1-d8111ac975fa","slug":"human-yars-fragment-chemotaxis","display_name":"Human leukocyte chemotaxis induced by YARS1 fragments","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b2848171-b9c5-5077-95e1-9ca11d4eb56d","stable_key":"63ce713e-6aea-59f6-9896-ca30e010b2ce:l-tyrosine-yars-c-domain-event","event_type":"observed_relationship","label":"A different part of the same protein has another signaling activity.","description":"A heptapeptide from the human YARS1 C-domain induced chemotaxis of mononuclear phagocytes and polymorphonuclear leukocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"12bddc89-7e35-5f30-8407-9039646ae9a4","slug":"human-yars1-c-terminal-fragment","display_name":"Human YARS1 C-terminal EMAPII-like fragment","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"51c668a9-1361-52af-b9e1-d8111ac975fa","slug":"human-yars-fragment-chemotaxis","display_name":"Human leukocyte chemotaxis induced by YARS1 fragments","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1e70f8cb-144f-5c63-b862-0c8670840077","slug":"yars1","display_name":"Human cytosolic tyrosyl-tRNA synthetase / YARS1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"C-domain peptide assays and sequence-specific controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Other proteins with similar motifs were inactive in these assays; sequence similarity alone is insufficient.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Tyrosine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A different part of the same protein has another signaling activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10438485/ · DOI 10.1074/jbc.274.33.23155","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c6ba1772-f597-5c96-a169-fc775a4560e2","evidence_kind":"source_excerpt","locator":"Lines 100-106","start_line":100,"end_line":106,"excerpt":"## l-tyrosine-yars-c-domain\nA different part of the same protein has another signaling activity.\nA heptapeptide from the human YARS1 C-domain induced chemotaxis of mononuclear phagocytes and polymorphonuclear leukocytes.\nModel: C-domain peptide assays and sequence-specific controls.\nLimitations: Other proteins with similar motifs were inactive in these assays; sequence similarity alone is insufficient.\nEvidence access: Primary abstract\nHighly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10438485/ · DOI 10.1074/jbc.274.33.23155","model_system":"C-domain peptide assays and sequence-specific controls.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"12917df2-c6e0-5b61-850f-dbff6d4b4d30","stable_key":"import-63ce713e-6aea-59f6-9896-ca30e010b2ce","title":"L-Tyrosine: catecholamines, thyroid chemistry, pigment, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7777f4440a8bfb14a04ff73e73392ccc45d8ee89f7853ecbcc0027d6f563b8a0","revision_id":"e1206111-3a75-5809-b8e9-231ff809ff1e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}