{"id":"2ba0ee8d-5ca9-5049-9402-4c03297984a5","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-chronic-excess-liver-injury","predicate":"chronic_excess_is_associated_with","statement":"Chronic vitamin A hepatotoxicity cases included cirrhosis and portal hypertension with characteristic hepatic storage-cell changes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1be3778f-ba98-51ff-827c-26768493abdb","mechanism_event_label":"Prolonged excess can damage the organ that stores vitamin A.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"3b8175a3-8dc5-5343-a49e-54af17fe4a40","slug":"liver-fibrosis","display_name":"Liver fibrosis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1be3778f-ba98-51ff-827c-26768493abdb","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-chronic-excess-liver-injury-event","event_type":"observed_intervention","label":"Prolonged excess can damage the organ that stores vitamin A.","description":"Chronic vitamin A hepatotoxicity cases included cirrhosis and portal hypertension with characteristic hepatic storage-cell changes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3b8175a3-8dc5-5343-a49e-54af17fe4a40","slug":"liver-fibrosis","display_name":"Liver fibrosis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"41 selected clinical cases with liver histology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Chronic preformed-vitamin-A exposure; excess, not deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Case series cannot estimate population incidence or define a safe-dose threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Prolonged excess can damage the organ that stores vitamin A.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-geubel1991] Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases (1991). https://pubmed.ncbi.nlm.nih.gov/2019375/ DOI: 10.1016/0016-5085(91)90672-8","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3cb229f-c125-51ed-9b51-a4348f69230e","evidence_kind":"source_excerpt","locator":"Lines 1834-1844","start_line":1834,"end_line":1844,"excerpt":"### va-chronic-excess-liver-injury\nChronic vitamin A hepatotoxicity cases included cirrhosis and portal hypertension with characteristic hepatic storage-cell changes.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Prolonged excess can damage the organ that stores vitamin A.\norganism: Homo sapiens\ntissue_or_cell_type: Liver\nexperimental_model: 41 selected clinical cases with liver histology.\nlimitations: Case series cannot estimate population incidence or define a safe-dose threshold.\nexposure: Chronic preformed-vitamin-A exposure; excess, not deficiency.\n[va-geubel1991] Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases (1991). https://pubmed.ncbi.nlm.nih.gov/2019375/ DOI: 10.1016/0016-5085(91)90672-8","model_system":"41 selected clinical cases with liver histology.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [va-geubel1991] Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases (1991). https://pubmed.ncbi.nlm.nih.gov/2019375/ DOI: 10.1016/0016-5085(91)90672-8","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}