{"id":"2b904321-8163-5486-b28b-7fd2845e54ae","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-fructoborate-knee-pain","predicate":"reduces","statement":"Calcium fructoborate reduced MPQ pain scores relative to placebo at day 7 (estimated difference −5.8, p=0.0009) and day 14 (−8.9, p<0.0001).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2a492054-d3b3-5a2b-99ce-f76623e44293","mechanism_event_label":"Participants reported less knee pain during this short trial.","subject":{"id":"ff3117ce-4dba-59de-a41c-dd181a43c42c","slug":"calcium-fructoborate","display_name":"Calcium fructoborate","entity_type_key":"small_molecule"},"object":{"id":"d3640b23-6895-555f-a018-2f2bdb969d3b","slug":"knee-pain-mpq-score","display_name":"Knee pain assessed by McGill Pain Questionnaire","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2a492054-d3b3-5a2b-99ce-f76623e44293","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-fructoborate-knee-pain-event","event_type":"observed_intervention","label":"Participants reported less knee pain during this short trial.","description":"Calcium fructoborate reduced MPQ pain scores relative to placebo at day 7 (estimated difference −5.8, p=0.0009) and day 14 (−8.9, p<0.0001).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ff3117ce-4dba-59de-a41c-dd181a43c42c","slug":"calcium-fructoborate","display_name":"Calcium fructoborate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d3640b23-6895-555f-a018-2f2bdb969d3b","slug":"knee-pain-mpq-score","display_name":"Knee pain assessed by McGill Pain Questionnaire","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/24940052.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"67109609237051de9522fd8d5c1dc3a6d96babf2f8b3931e4564c675f88c80be\", \"start_char\": 0, \"end_char\": 1393, \"text_sha256\": \"67109609237051de9522fd8d5c1dc3a6d96babf2f8b3931e4564c675f88c80be\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized placebo-controlled trial; 60 participants with self-reported knee discomfort","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Calcium fructoborate 110 mg twice daily for 14 days; compound mass is not elemental boron dose","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short symptom trial. The 2021 correction (PMID 33564230, https://pubmed.ncbi.nlm.nih.gov/33564230/) disclosed FutureCeuticals funding/product supply, company employment and patent interests; the journal requested retrospective registration. Day-seven WOMAC p=0.06 was not conventionally significant despite broader wording in the original abstract. These are corrections/qualifications, not a new scientific conflict.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Participants reported less knee pain during this short trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p24940052] Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study. (2014). https://pubmed.ncbi.nlm.nih.gov/24940052/ DOI: 10.2147/cia.s64590","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Pain and WOMAC questionnaire outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b439e75f-8d7f-5598-8dca-3fbab1959885","evidence_kind":"source_excerpt","locator":"Lines 1067-1078","start_line":1067,"end_line":1078,"excerpt":"### boron-fructoborate-knee-pain\nCalcium fructoborate reduced MPQ pain scores relative to placebo at day 7 (estimated difference −5.8, p=0.0009) and day 14 (−8.9, p<0.0001).\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Participants reported less knee pain during this short trial.\norganism: Human\ntissue_or_cell_type: Pain and WOMAC questionnaire outcomes\nexperimental_model: Randomized placebo-controlled trial; 60 participants with self-reported knee discomfort\nlimitations: Short symptom trial. The 2021 correction (PMID 33564230, https://pubmed.ncbi.nlm.nih.gov/33564230/) disclosed FutureCeuticals funding/product supply, company employment and patent interests; the journal requested retrospective registration. Day-seven WOMAC p=0.06 was not conventionally significant despite broader wording in the original abstract. These are corrections/qualifications, not a new scientific conflict.\nexposure: Calcium fructoborate 110 mg twice daily for 14 days; compound mass is not elemental boron dose\nevidence_span: {\"source_cache\": \"artifacts/boron-research/24940052.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"67109609237051de9522fd8d5c1dc3a6d96babf2f8b3931e4564c675f88c80be\", \"start_char\": 0, \"end_char\": 1393, \"text_sha256\": \"67109609237051de9522fd8d5c1dc3a6d96babf2f8b3931e4564c675f88c80be\"}\n[boron-p24940052] Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study. 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