{"id":"2b74f544-2a1d-5dc5-9806-ab1ee4afe0b0","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-oatp1b1-inhibition-glucuronide","predicate":"inhibits","statement":"Luteolin 3′-O-glucuronide strongly inhibited OATP1B1 in vitro.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"32666a72-9a25-5b85-87b7-376fcb9c2a81","mechanism_event_label":"A transported metabolite can also compete with uptake.","subject":{"id":"3249c76e-5379-5540-9d6b-9ad0de95d29b","slug":"luteolin-3-prime-o-glucuronide","display_name":"Luteolin 3′-O-glucuronide","entity_type_key":"small_molecule"},"object":{"id":"38b2f200-15ca-5db6-8d7e-2b78ee490eda","slug":"slco1b1","display_name":"Human OATP1B1 / SLCO1B1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"32666a72-9a25-5b85-87b7-376fcb9c2a81","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-oatp1b1-inhibition-glucuronide-event","event_type":"observed_relationship","label":"A transported metabolite can also compete with uptake.","description":"Luteolin 3′-O-glucuronide strongly inhibited OATP1B1 in vitro.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3249c76e-5379-5540-9d6b-9ad0de95d29b","slug":"luteolin-3-prime-o-glucuronide","display_name":"Luteolin 3′-O-glucuronide","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"38b2f200-15ca-5db6-8d7e-2b78ee490eda","slug":"slco1b1","display_name":"Human OATP1B1 / SLCO1B1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human transporter interaction assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No clinical drug-exposure change was measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A transported metabolite can also compete with uptake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36481402/ · DOI 10.1016/j.biopha.2022.114078","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5d0ef5fe-64fe-5766-a24a-ee679ef3bfa0","evidence_kind":"source_excerpt","locator":"Lines 228-234","start_line":228,"end_line":234,"excerpt":"## luteolin-oatp1b1-inhibition-glucuronide\nA transported metabolite can also compete with uptake.\nLuteolin 3′-O-glucuronide strongly inhibited OATP1B1 in vitro.\nModel: Human transporter interaction assays.\nLimitations: No clinical drug-exposure change was measured.\nEvidence access: Primary abstract\nInteraction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36481402/ · DOI 10.1016/j.biopha.2022.114078","model_system":"Human transporter interaction assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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