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(2003). https://pubmed.ncbi.nlm.nih.gov/12663510/ DOI: 10.1093/carcin/24.3.497","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thioredoxin reductase regulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e9961d9f-d1d9-5f38-914f-c158274cb963","evidence_kind":"source_excerpt","locator":"Lines 697-708","start_line":697,"end_line":708,"excerpt":"### sulforaphane-txnrd1-transcription\nSulforaphane increased TXNRD1 mRNA up to fourfold; TXNRD2 mRNA did not show this induction.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One cytosolic enzyme gene responded while the mitochondrial counterpart did not.\norganism: Human HepG2 hepatoma cells\ntissue_or_cell_type: Thioredoxin reductase regulation\nexperimental_model: Transcription/translation and inhibitor experiments\nlimitations: Cell-culture synergy at specified exposures is not a clinical supplement recommendation; TXNRD1 and TXNRD2 were not interchangeable.\nexposure: Sulforaphane, sodium selenite, combined treatment and pathway inhibitors\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/12663510.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"95f1de031ede41aa12f975dff28193dcb426465d4bda94bb84d4e60ef6c292b9\", \"start_char\": 0, \"end_char\": 1535, \"text_sha256\": \"95f1de031ede41aa12f975dff28193dcb426465d4bda94bb84d4e60ef6c292b9\"}\n[sulforaphane-p12663510] Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. 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